Understanding the function of regulatory DNA interactions in the interpretation of non-coding GWAS variants

Understanding the function of regulatory DNA interactions in the interpretation of non-coding GWAS variants

Genome-wide association studies (GWAS) have identified a vast number of variants associated with various complex human diseases and traits. However, most of these GWAS variants reside in non-coding regions producing no proteins, making the interpretation of these variants a daunting challenge. Prior...

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Bibliographic Details
Main Authors:	Wujuan Zhong, Weifang Liu, Jiawen Chen, Quan Sun, Ming Hu, Yun Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	3D genome organization GWAS variants non-coding DNA variation Hi-C TADs FIREs
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.957292/full

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