The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia
Abstract Introduction Schizophrenia's heritability and familial transmission have been known for several decades. The male‐specific Y chromosome plays an important role in schizophrenia. Short tandem repeats (STRs)have been recognized as risk genes in the development of schizophrenia. Here, we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2637 |
| _version_ | 1811288641548320768 |
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| author | Chun Yang Huajie Ba Huihui Zou Xianju Zhou |
| author_facet | Chun Yang Huajie Ba Huihui Zou Xianju Zhou |
| author_sort | Chun Yang |
| collection | DOAJ |
| description | Abstract Introduction Schizophrenia's heritability and familial transmission have been known for several decades. The male‐specific Y chromosome plays an important role in schizophrenia. Short tandem repeats (STRs)have been recognized as risk genes in the development of schizophrenia. Here, we investigated the association between male schizophrenia and Y‐chromosomal STRs loci. Methods We recruited 355 patients with schizophrenia and 473 healthy males for physical examination and amplified them with a PowerPlex 21 System fluorescence‐labeled composite amplification System. Then, the resultant products were separated by electrophoresis and further detected. Finally, differences in allele and genotype frequency distributions of STR loci were observed. Results Our results showed that all 20 STR loci were in accordance with Hardy–Weinberg's law (p > .05). There were statistically significant differences in alleles of D13S317 and D5S818 loci and genotype frequency distribution between the two groups (alleles: p = .039, p = .022, respectively; genotype: p = .0004, p = .011, respectively). However, there was no difference in the other autosomal 18 STR loci between the two groups (p > .05). Univariate analysis showed that the frequency distribution differences of allele 11 and genotype 10‐11 at the D13S317 locus between the two groups were significant (compared to the controls, p = 0.005, odds ratio (OR) = 1.37, 95%b confidence interval (CI) = 1.10–1.71, compared to the controls, p = .0000002, OR = 3.92, 95% CI = 2.27–6.77, respectively). The frequency distribution differences of allele 7 and genotype 7‐10 at D5S818 between the two groups were significant (compared to the controls, p = .0006, OR = 3.42, 95% CI = 1.63–7.16, compared to the controls, p = .0011, OR = 8.24, 95% CI = 1.83–37.05, respectively). Conclusion Polymorphisms of the D13S317 and D5S818 loci may be predisposing factors for schizophrenia. |
| first_indexed | 2024-04-13T03:40:54Z |
| format | Article |
| id | doaj.art-f0df3cd037994106868c585bc83ff61a |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-04-13T03:40:54Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-f0df3cd037994106868c585bc83ff61a2022-12-22T03:04:10ZengWileyBrain and Behavior2162-32792022-07-01127n/an/a10.1002/brb3.2637The association of 20 short tandem repeat loci of autosomal chromosome with male schizophreniaChun Yang0Huajie Ba1Huihui Zou2Xianju Zhou3The 904th Hospital (Changzhou Branch) of Joint Logistic Support Force of Chinese People's Liberation Army Changzhou Jiangsu Province ChinaDNA Laboratory Public Security Bureau of Changzhou Changzhou Jiangsu Province ChinaSpecial Medical Service Center, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong ChinaSpecial Medical Service Center, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong ChinaAbstract Introduction Schizophrenia's heritability and familial transmission have been known for several decades. The male‐specific Y chromosome plays an important role in schizophrenia. Short tandem repeats (STRs)have been recognized as risk genes in the development of schizophrenia. Here, we investigated the association between male schizophrenia and Y‐chromosomal STRs loci. Methods We recruited 355 patients with schizophrenia and 473 healthy males for physical examination and amplified them with a PowerPlex 21 System fluorescence‐labeled composite amplification System. Then, the resultant products were separated by electrophoresis and further detected. Finally, differences in allele and genotype frequency distributions of STR loci were observed. Results Our results showed that all 20 STR loci were in accordance with Hardy–Weinberg's law (p > .05). There were statistically significant differences in alleles of D13S317 and D5S818 loci and genotype frequency distribution between the two groups (alleles: p = .039, p = .022, respectively; genotype: p = .0004, p = .011, respectively). However, there was no difference in the other autosomal 18 STR loci between the two groups (p > .05). Univariate analysis showed that the frequency distribution differences of allele 11 and genotype 10‐11 at the D13S317 locus between the two groups were significant (compared to the controls, p = 0.005, odds ratio (OR) = 1.37, 95%b confidence interval (CI) = 1.10–1.71, compared to the controls, p = .0000002, OR = 3.92, 95% CI = 2.27–6.77, respectively). The frequency distribution differences of allele 7 and genotype 7‐10 at D5S818 between the two groups were significant (compared to the controls, p = .0006, OR = 3.42, 95% CI = 1.63–7.16, compared to the controls, p = .0011, OR = 8.24, 95% CI = 1.83–37.05, respectively). Conclusion Polymorphisms of the D13S317 and D5S818 loci may be predisposing factors for schizophrenia.https://doi.org/10.1002/brb3.2637alleleautosomal chromosomehaplotypeschizophreniashort tandem repeats |
| spellingShingle | Chun Yang Huajie Ba Huihui Zou Xianju Zhou The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia Brain and Behavior allele autosomal chromosome haplotype schizophrenia short tandem repeats |
| title | The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia |
| title_full | The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia |
| title_fullStr | The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia |
| title_full_unstemmed | The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia |
| title_short | The association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia |
| title_sort | association of 20 short tandem repeat loci of autosomal chromosome with male schizophrenia |
| topic | allele autosomal chromosome haplotype schizophrenia short tandem repeats |
| url | https://doi.org/10.1002/brb3.2637 |
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