Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma

Gene expression signatures modulated by epidermal growth factor receptor activation and their relationship to cetuximab resistance in head and neck squamous cell carcinoma

<p>Abstract</p> <p>Background</p> <p>Aberrant activation of signaling pathways downstream of epidermal growth factor receptor (EGFR) has been hypothesized to be one of the mechanisms of cetuximab (a monoclonal antibody against EGFR) resistance in head and neck squamous...

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Bibliographic Details
Main Authors: Fertig Elana J, Ren Qing, Cheng Haixia, Hatakeyama Hiromitsu, Dicker Adam P, Rodeck Ulrich, Considine Michael, Ochs Michael F, Chung Christine H
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/13/160

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