Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study
IntroductionPost-stroke cognitive impairment (PSCI) cannot be neglected because it drastically influences the daily life of patients and their families. However, there are no studies exploring the association between preclinical blood biomarkers of neurodegeneration including plasma amyloid-β (Aβ),...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.889101/full |
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| author | Li-Kai Huang Li-Kai Huang Li-Kai Huang Li-Kai Huang Li-Kai Huang Shu-Ping Chao Shu-Ping Chao Shu-Ping Chao Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Li-Nien Chien Li-Nien Chien Li-Nien Chien Hung-Yi Chiou Hung-Yi Chiou Hung-Yi Chiou Yu-Chun Lo Yi-Chen Hsieh Yi-Chen Hsieh Yi-Chen Hsieh |
| author_facet | Li-Kai Huang Li-Kai Huang Li-Kai Huang Li-Kai Huang Li-Kai Huang Shu-Ping Chao Shu-Ping Chao Shu-Ping Chao Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Li-Nien Chien Li-Nien Chien Li-Nien Chien Hung-Yi Chiou Hung-Yi Chiou Hung-Yi Chiou Yu-Chun Lo Yi-Chen Hsieh Yi-Chen Hsieh Yi-Chen Hsieh |
| author_sort | Li-Kai Huang |
| collection | DOAJ |
| description | IntroductionPost-stroke cognitive impairment (PSCI) cannot be neglected because it drastically influences the daily life of patients and their families. However, there are no studies exploring the association between preclinical blood biomarkers of neurodegeneration including plasma amyloid-β (Aβ), tau, and brain-derived neurotrophic factor (BDNF) together with the risk of PSCI. This longitudinal study was to investigate whether these blood biomarkers with imaging markers of cerebral small vessel disease can improve the prediction for PSCI. In addition, we also explored the association between blood biomarkers with the trajectories of PSCI.MethodsAdult patients with first-ever acute ischemic stroke were recruited, and the cognitive and functional abilities of these patients were evaluated. Furthermore, blood biomarkers of neurodegeneration including plasma Aβ-40, Aβ-42, total tau, phosphorylated tau 181 (p-tau181), and BDNF levels and image markers of cerebral small vessel disease were measured. Each patient was followed up at 3 and 12 months at the outpatient department.ResultsOf 136 patients, 40 and 50 patients developed PSCI at 3 and 12 months after stroke, respectively. In functional trajectories, 27 patients did not have PSCI at 3 months but did at 12 months. By contrast, the PSCI status of 17 patients at 3 months was reversed at 12 months. Patients with high-acute plasma p-tau181 had a significantly lower PSCI risk at 3 months (odds ratio [OR] = 0.62, 95% CI = 0.40–0.94, p = 0.0243) and 12 months (OR = 0.69, 95% CI = 0.47–0.99, p = 0.0443) after adjustment for covariates and image biomarkers. Discrimination and reclassification statistics indicated that the p-tau181 level can improve discrimination ability for PSCI at 3 and 12 months, respectively. In addition, the plasma p-tau181 level was the highest in subjects without PSCI followed by those with delayed-onset PSCI and early-onset PSCI with reversal, whereas the lowest plasma p-tau181 level was found among those with persistent PSCI, showing a significant trend test (p = 0.0081).ConclusionPlasma p-tau181 is a potential biomarker for predicting early- and delayed-onset PSCI. Future studies should incorporate plasma p-tau181 as an indicator for timely cognitive intervention in the follow-up of patients with stroke. |
| first_indexed | 2024-04-14T06:58:35Z |
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| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-14T06:58:35Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f0e1567622ff41b3a217f362f9ce0a1d2022-12-22T02:06:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-04-011410.3389/fnagi.2022.889101889101Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal StudyLi-Kai Huang0Li-Kai Huang1Li-Kai Huang2Li-Kai Huang3Li-Kai Huang4Shu-Ping Chao5Shu-Ping Chao6Shu-Ping Chao7Chaur-Jong Hu8Chaur-Jong Hu9Chaur-Jong Hu10Chaur-Jong Hu11Chaur-Jong Hu12Li-Nien Chien13Li-Nien Chien14Li-Nien Chien15Hung-Yi Chiou16Hung-Yi Chiou17Hung-Yi Chiou18Yu-Chun Lo19Yi-Chen Hsieh20Yi-Chen Hsieh21Yi-Chen Hsieh22Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanGraduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, TaiwanTaipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanPh.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanTaipei Neuroscience Institute, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanGraduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institution of Data Science, College of Management, Taipei Medical University, Taipei, TaiwanSchool of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan0Health Data Analytics and Statistics Center, Office of Data Science, Taipei Medical University, Taipei, Taiwan1Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan2Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan3School of Public Health, College of Public Health, Taipei Medical University, Taipei, TaiwanGraduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan2Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan4Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, TaiwanIntroductionPost-stroke cognitive impairment (PSCI) cannot be neglected because it drastically influences the daily life of patients and their families. However, there are no studies exploring the association between preclinical blood biomarkers of neurodegeneration including plasma amyloid-β (Aβ), tau, and brain-derived neurotrophic factor (BDNF) together with the risk of PSCI. This longitudinal study was to investigate whether these blood biomarkers with imaging markers of cerebral small vessel disease can improve the prediction for PSCI. In addition, we also explored the association between blood biomarkers with the trajectories of PSCI.MethodsAdult patients with first-ever acute ischemic stroke were recruited, and the cognitive and functional abilities of these patients were evaluated. Furthermore, blood biomarkers of neurodegeneration including plasma Aβ-40, Aβ-42, total tau, phosphorylated tau 181 (p-tau181), and BDNF levels and image markers of cerebral small vessel disease were measured. Each patient was followed up at 3 and 12 months at the outpatient department.ResultsOf 136 patients, 40 and 50 patients developed PSCI at 3 and 12 months after stroke, respectively. In functional trajectories, 27 patients did not have PSCI at 3 months but did at 12 months. By contrast, the PSCI status of 17 patients at 3 months was reversed at 12 months. Patients with high-acute plasma p-tau181 had a significantly lower PSCI risk at 3 months (odds ratio [OR] = 0.62, 95% CI = 0.40–0.94, p = 0.0243) and 12 months (OR = 0.69, 95% CI = 0.47–0.99, p = 0.0443) after adjustment for covariates and image biomarkers. Discrimination and reclassification statistics indicated that the p-tau181 level can improve discrimination ability for PSCI at 3 and 12 months, respectively. In addition, the plasma p-tau181 level was the highest in subjects without PSCI followed by those with delayed-onset PSCI and early-onset PSCI with reversal, whereas the lowest plasma p-tau181 level was found among those with persistent PSCI, showing a significant trend test (p = 0.0081).ConclusionPlasma p-tau181 is a potential biomarker for predicting early- and delayed-onset PSCI. Future studies should incorporate plasma p-tau181 as an indicator for timely cognitive intervention in the follow-up of patients with stroke.https://www.frontiersin.org/articles/10.3389/fnagi.2022.889101/fullearly-onset PSCIdelayed-onset PSCIp-tau181ischemic strokebiomarker |
| spellingShingle | Li-Kai Huang Li-Kai Huang Li-Kai Huang Li-Kai Huang Li-Kai Huang Shu-Ping Chao Shu-Ping Chao Shu-Ping Chao Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Chaur-Jong Hu Li-Nien Chien Li-Nien Chien Li-Nien Chien Hung-Yi Chiou Hung-Yi Chiou Hung-Yi Chiou Yu-Chun Lo Yi-Chen Hsieh Yi-Chen Hsieh Yi-Chen Hsieh Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study Frontiers in Aging Neuroscience early-onset PSCI delayed-onset PSCI p-tau181 ischemic stroke biomarker |
| title | Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study |
| title_full | Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study |
| title_fullStr | Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study |
| title_full_unstemmed | Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study |
| title_short | Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study |
| title_sort | plasma phosphorylated tau181 is a predictor of post stroke cognitive impairment a longitudinal study |
| topic | early-onset PSCI delayed-onset PSCI p-tau181 ischemic stroke biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.889101/full |
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