Effect of the Cannabinoid Agonist WIN 55,212-2 on Neuropathic and Visceral Pain Induced by a Non-Diarrheagenic Dose of the Antitumoral Drug 5-Fluorouracil in the Rat

Effect of the Cannabinoid Agonist WIN 55,212-2 on Neuropathic and Visceral Pain Induced by a Non-Diarrheagenic Dose of the Antitumoral Drug 5-Fluorouracil in the Rat

5-fluorouracil (5-FU) is an antineoplastic drug used to treat colorectal cancer, but it causes, among other adverse effects, diarrhea and mucositis, as well as enteric neuropathy, as shown in experimental animals. It might also cause neuropathic pain and alterations in visceral sensitivity, but this...

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Bibliographic Details
Main Authors: Gema Vera, Laura López-Gómez, Rocío Girón, María Isabel Martín-Fontelles, Kulmira Nurgali, Raquel Abalo, José Antonio Uranga
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
cancer chemotherapy
cannabinoid
chemotherapy-induced adverse effects
gastrointestinal motor function
peripheral neuropathy
visceral pain
Online Access:https://www.mdpi.com/1422-0067/24/19/14430

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