DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice

DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice

IntroductionThe incidence of Lyme disease (LD) in Canada and the United States has risen over the last decade, nearing 480,000 cases each year. Borrelia burgdorferi sensu lato, the causative agent of LD, is transmitted to humans through the bite of an infected tick, resulting in flu-like symptoms an...

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Bibliographic Details
Main Authors: Annabelle Pfeifle, Sathya N. Thulasi Raman, Casey Lansdell, Wanyue Zhang, Levi Tamming, Jonathon Cecillon, Emmanuel Laryea, Devina Patel, Jianguo Wu, Caroline Gravel, Grant Frahm, Jun Gao, Wangxue Chen, George Chaconas, Simon Sauve, Michael Rosu-Myles, Lisheng Wang, Michael J. W. Johnston, Xuguang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
Lyme disease
lipid nanoparticle
outer surface protein C
antibodies
carditis
lymphadenopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1020134/full

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