Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data

Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data

Abstract Background: Overall survival of advanced colorectal cancer (CRC) patients remains poor, and gene expression analysis could potentially complement detection of clinically relevant mutations to personalize CRC treatments. Methods: We performed RNA sequencing of formalin-fixed, paraffin-embedd...

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Bibliographic Details
Main Authors: Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang, Anton Buzdin
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Cancer
Subjects:
Transcriptomics
RNA sequencing
Molecular diagnostics
Biomarkers detection
Colorectal cancer
Targeted therapy
Online Access:https://doi.org/10.1186/s12885-022-10177-3

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