Novel Methods for Liposome Formulation: Advancements and Innovations
Liposomes are nanoscale spheroidal vesicles, predominantly composed of phospholipids, that offer a hydrophilic core surrounded by a hydrophobic bilayer. Their unique structure endows them with excellent biocompatibility and the ability to house both hydrophilic and lipophilic agents, making them exc...
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| Format: | Article |
| Language: | English |
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AcademicPres
2023-11-01
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| Series: | Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology |
| Subjects: | |
| Online Access: | https://journals.usamvcluj.ro/index.php/fst/article/view/14694 |
| _version_ | 1797299856422731776 |
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| author | Bianca ENARU Anca FĂRCAŞ Andreea STĂNILĂ Sonia SOCACI Zoriţa DIACONEASA |
| author_facet | Bianca ENARU Anca FĂRCAŞ Andreea STĂNILĂ Sonia SOCACI Zoriţa DIACONEASA |
| author_sort | Bianca ENARU |
| collection | DOAJ |
| description | Liposomes are nanoscale spheroidal vesicles, predominantly composed of phospholipids, that offer a hydrophilic core surrounded by a hydrophobic bilayer. Their unique structure endows them with excellent biocompatibility and the ability to house both hydrophilic and lipophilic agents, making them exceptionally suited for targeted delivery applications. This versatility has seen liposomes gain widespread use in various industries, including medicine, pharmaceuticals, and nutraceuticals. This comprehensive review meticulously examines the spectrum of liposome fabrication techniques, providing insight into their respective advantages and limitations. Specifically, we scrutinize methods such as reverse phase evaporation, freeze drying, the Bangham method (also known as the thin film hydration technique), ethanol injection, the emulsion method, and ultrasonication. Each of these methodologies contributes to the array of liposomal forms, influencing their final characteristics and suitability for different applications. The present review categorizes liposomes based on the fabrication technique, offering a comparative perspective that is instrumental for researchers and practitioners in selecting the optimal method for their specific delivery system needs. |
| first_indexed | 2024-03-07T22:57:43Z |
| format | Article |
| id | doaj.art-f0e7197b2d8346e08b208db71ed49ec3 |
| institution | Directory Open Access Journal |
| issn | 2344-2344 2344-5300 |
| language | English |
| last_indexed | 2024-03-07T22:57:43Z |
| publishDate | 2023-11-01 |
| publisher | AcademicPres |
| record_format | Article |
| series | Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology |
| spelling | doaj.art-f0e7197b2d8346e08b208db71ed49ec32024-02-22T22:16:47ZengAcademicPresBulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology2344-23442344-53002023-11-0180211310.15835/buasvmcn-fst:2023.000414694Novel Methods for Liposome Formulation: Advancements and InnovationsBianca ENARU0Anca FĂRCAŞ1Andreea STĂNILĂ2Sonia SOCACI3Zoriţa DIACONEASA4Faculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur, 3-5, 400372, Cluj-NapocaFaculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur, 3-5, 400372, Cluj-NapocaFaculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur, 3-5, 400372, Cluj-NapocaFaculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur, 3-5, 400372, Cluj-NapocaFaculty of Food Science and Technology, University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Calea Mănăştur, 3-5, 400372, Cluj-NapocaLiposomes are nanoscale spheroidal vesicles, predominantly composed of phospholipids, that offer a hydrophilic core surrounded by a hydrophobic bilayer. Their unique structure endows them with excellent biocompatibility and the ability to house both hydrophilic and lipophilic agents, making them exceptionally suited for targeted delivery applications. This versatility has seen liposomes gain widespread use in various industries, including medicine, pharmaceuticals, and nutraceuticals. This comprehensive review meticulously examines the spectrum of liposome fabrication techniques, providing insight into their respective advantages and limitations. Specifically, we scrutinize methods such as reverse phase evaporation, freeze drying, the Bangham method (also known as the thin film hydration technique), ethanol injection, the emulsion method, and ultrasonication. Each of these methodologies contributes to the array of liposomal forms, influencing their final characteristics and suitability for different applications. The present review categorizes liposomes based on the fabrication technique, offering a comparative perspective that is instrumental for researchers and practitioners in selecting the optimal method for their specific delivery system needs.https://journals.usamvcluj.ro/index.php/fst/article/view/14694liposome formulationdrug deliveryencapsulationlipid bilayersnanotechnology |
| spellingShingle | Bianca ENARU Anca FĂRCAŞ Andreea STĂNILĂ Sonia SOCACI Zoriţa DIACONEASA Novel Methods for Liposome Formulation: Advancements and Innovations Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Food Science and Technology liposome formulation drug delivery encapsulation lipid bilayers nanotechnology |
| title | Novel Methods for Liposome Formulation: Advancements and Innovations |
| title_full | Novel Methods for Liposome Formulation: Advancements and Innovations |
| title_fullStr | Novel Methods for Liposome Formulation: Advancements and Innovations |
| title_full_unstemmed | Novel Methods for Liposome Formulation: Advancements and Innovations |
| title_short | Novel Methods for Liposome Formulation: Advancements and Innovations |
| title_sort | novel methods for liposome formulation advancements and innovations |
| topic | liposome formulation drug delivery encapsulation lipid bilayers nanotechnology |
| url | https://journals.usamvcluj.ro/index.php/fst/article/view/14694 |
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