Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice
Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer’s disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possibl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2005-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319321425 |
| _version_ | 1811230869383282688 |
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| author | Eun-Joo Shin Jin Hyeong Jhoo Toshitaka Nabeshima Wang-Kee Jhoo Myung Sang Kwon Yong Kwang Lim Jong Seok Chae Myung Eun Jung Seok Joo Park Kyung Jin Jang Hyoung-Chun Kim |
| author_facet | Eun-Joo Shin Jin Hyeong Jhoo Toshitaka Nabeshima Wang-Kee Jhoo Myung Sang Kwon Yong Kwang Lim Jong Seok Chae Myung Eun Jung Seok Joo Park Kyung Jin Jang Hyoung-Chun Kim |
| author_sort | Eun-Joo Shin |
| collection | DOAJ |
| description | Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer’s disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1 – 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1 – 42). Keywords:: growth hormone releaser, amyloid beta protein, cognitive enhancer |
| first_indexed | 2024-04-12T10:36:32Z |
| format | Article |
| id | doaj.art-f0e778d05bd24e088cb9b42faf77a3c0 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-12T10:36:32Z |
| publishDate | 2005-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-f0e778d05bd24e088cb9b42faf77a3c02022-12-22T03:36:43ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-01991117120Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in MiceEun-Joo Shin0Jin Hyeong Jhoo1Toshitaka Nabeshima2Wang-Kee Jhoo3Myung Sang Kwon4Yong Kwang Lim5Jong Seok Chae6Myung Eun Jung7Seok Joo Park8Kyung Jin Jang9Hyoung-Chun Kim10Neurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, JapanDepartment of Psychiatry, Pundang Jesaeng Hospital, Daejin Medical Center, Seongnam 463-774, KoreaDepartment of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, JapanNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaFaculty of Veterinary Medicine, Kangwon National University and Biosoft Technolgoies Inc., Biotechonologey Innovation Center, Hi-tech Venture Town, Chunchon 200-701, KoreaNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, KoreaNeurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea; Corresponding author. FAX: +82-33-255-7865 E-mail: kimhc@kangwon.ac.krAccumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer’s disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Aβ) (1 – 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Aβ (1 – 42). Keywords:: growth hormone releaser, amyloid beta protein, cognitive enhancerhttp://www.sciencedirect.com/science/article/pii/S1347861319321425 |
| spellingShingle | Eun-Joo Shin Jin Hyeong Jhoo Toshitaka Nabeshima Wang-Kee Jhoo Myung Sang Kwon Yong Kwang Lim Jong Seok Chae Myung Eun Jung Seok Joo Park Kyung Jin Jang Hyoung-Chun Kim Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice Journal of Pharmacological Sciences |
| title | Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice |
| title_full | Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice |
| title_fullStr | Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice |
| title_full_unstemmed | Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice |
| title_short | Growth Hormone Releaser Attenuates β-Amyloid (1 – 42)-Induced Memory Impairment in Mice |
| title_sort | growth hormone releaser attenuates β amyloid 1 42 induced memory impairment in mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319321425 |
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