Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy

Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is caused by DMD mutations leading to dystrophin loss. Full‐length Dp427 is the primary dystrophin isoform expressed in muscle and is also expressed in the central nervous system (CNS). Two shorter isoforms, Dp140 and Dp71, are highly expressed i...

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Bibliographic Details
Main Authors: Mary Chesshyre, Deborah Ridout, Yasumasa Hashimoto, Yoko Ookubo, Silvia Torelli, Kate Maresh, Valeria Ricotti, Lianne Abbott, Vandana Ayyar Gupta, Marion Main, Giulia Ferrari, Anna Kowala, Yung‐Yao Lin, Francesco Saverio Tedesco, Mariacristina Scoto, Giovanni Baranello, Adnan Manzur, Yoshitsugu Aoki, Francesco Muntoni
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Duchenne muscular dystrophy
Isoform
Motor function
Online Access:https://doi.org/10.1002/jcsm.12914

Internet

https://doi.org/10.1002/jcsm.12914

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