Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination
Mass vaccination against coronavirus disease 2019 (COVID-19) is a global health strategy to control the COVID-19 pandemic. With the increasing number of vaccinations, COVID-19 vaccine-associated lymphadenopathy (C19-VAL) has been frequently reported. Current findings emphasize the characteristics of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/3/696 |
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| author | Tzu-Chuan Ho Daniel Hueng-Yuan Shen Chin-Chuan Chang Hung-Pin Chan Kuo-Pin Chuang Cheng-Hui Yuan Ciao-Ning Chen Ming-Hui Yang Yu-Chang Tyan |
| author_facet | Tzu-Chuan Ho Daniel Hueng-Yuan Shen Chin-Chuan Chang Hung-Pin Chan Kuo-Pin Chuang Cheng-Hui Yuan Ciao-Ning Chen Ming-Hui Yang Yu-Chang Tyan |
| author_sort | Tzu-Chuan Ho |
| collection | DOAJ |
| description | Mass vaccination against coronavirus disease 2019 (COVID-19) is a global health strategy to control the COVID-19 pandemic. With the increasing number of vaccinations, COVID-19 vaccine-associated lymphadenopathy (C19-VAL) has been frequently reported. Current findings emphasize the characteristics of C19-VAL. The mechanism of C19-VAL is complicated to explore. Accumulated reports separately show that C19-VAL incidence is associated with receiver age and gender, reactive change within lymph nodes (LN), etc. We constructed a systematic review to evaluate the associated elements of C19-VAL and provide the mechanism of C19-VAL. Articles were searched from PubMed, Web of Science and EMBASE by using the processing of PRISMA. The search terms included combinations of the COVID-19 vaccine, COVID-19 vaccination and lymphadenopathy. Finally, sixty-two articles have been included in this study. Our results show that days post-vaccination and B cell germinal center response are negatively correlated with C19-VAL incidence. The reactive change within LN is highly related to C19-VAL development. The study results suggested that strong vaccine immune response may contribute to the C19-VAL development and perhaps through the B cell germinal center response post vaccination. From the perspective of imaging interpretation, it is important to carefully distinguish reactive lymph nodes from metastatic lymph node enlargement through medical history collection or evaluation, especially in patients with underlying malignancy. |
| first_indexed | 2024-03-11T05:47:39Z |
| format | Article |
| id | doaj.art-f0ec17ab36b34bb4a8813ded7673b122 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T05:47:39Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-f0ec17ab36b34bb4a8813ded7673b1222023-11-17T14:19:43ZengMDPI AGVaccines2076-393X2023-03-0111369610.3390/vaccines11030696Immune Response Related to Lymphadenopathy Post COVID-19 VaccinationTzu-Chuan Ho0Daniel Hueng-Yuan Shen1Chin-Chuan Chang2Hung-Pin Chan3Kuo-Pin Chuang4Cheng-Hui Yuan5Ciao-Ning Chen6Ming-Hui Yang7Yu-Chang Tyan8Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDepartment of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanGraduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, TaiwanMass Spectrometry Laboratory, Department of Chemistry, National University of Singapore, Singapore 119077, SingaporeDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, TaiwanMass vaccination against coronavirus disease 2019 (COVID-19) is a global health strategy to control the COVID-19 pandemic. With the increasing number of vaccinations, COVID-19 vaccine-associated lymphadenopathy (C19-VAL) has been frequently reported. Current findings emphasize the characteristics of C19-VAL. The mechanism of C19-VAL is complicated to explore. Accumulated reports separately show that C19-VAL incidence is associated with receiver age and gender, reactive change within lymph nodes (LN), etc. We constructed a systematic review to evaluate the associated elements of C19-VAL and provide the mechanism of C19-VAL. Articles were searched from PubMed, Web of Science and EMBASE by using the processing of PRISMA. The search terms included combinations of the COVID-19 vaccine, COVID-19 vaccination and lymphadenopathy. Finally, sixty-two articles have been included in this study. Our results show that days post-vaccination and B cell germinal center response are negatively correlated with C19-VAL incidence. The reactive change within LN is highly related to C19-VAL development. The study results suggested that strong vaccine immune response may contribute to the C19-VAL development and perhaps through the B cell germinal center response post vaccination. From the perspective of imaging interpretation, it is important to carefully distinguish reactive lymph nodes from metastatic lymph node enlargement through medical history collection or evaluation, especially in patients with underlying malignancy.https://www.mdpi.com/2076-393X/11/3/696COVID-19C19-VALlymphadenopathylymph node |
| spellingShingle | Tzu-Chuan Ho Daniel Hueng-Yuan Shen Chin-Chuan Chang Hung-Pin Chan Kuo-Pin Chuang Cheng-Hui Yuan Ciao-Ning Chen Ming-Hui Yang Yu-Chang Tyan Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination Vaccines COVID-19 C19-VAL lymphadenopathy lymph node |
| title | Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination |
| title_full | Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination |
| title_fullStr | Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination |
| title_full_unstemmed | Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination |
| title_short | Immune Response Related to Lymphadenopathy Post COVID-19 Vaccination |
| title_sort | immune response related to lymphadenopathy post covid 19 vaccination |
| topic | COVID-19 C19-VAL lymphadenopathy lymph node |
| url | https://www.mdpi.com/2076-393X/11/3/696 |
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