Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism
To investigate the anti-obesity effect of a noni (Morinda citrifolia L.) fruit polysaccharide (NFP) and its potential mechanisms, 24 male C57BL/6J mice were randomly divided into three groups—normal control group, high-fat diet (HFD) group, and NFP-administration group and were gavaged once a day fo...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000087 |
| _version_ | 1828041988237164544 |
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| author | Wenjing Mo Jiaqi Zou Ming Wu Zijun Peng Wenjiang He Wenzhi Li Xiaoyong Wu |
| author_facet | Wenjing Mo Jiaqi Zou Ming Wu Zijun Peng Wenjiang He Wenzhi Li Xiaoyong Wu |
| author_sort | Wenjing Mo |
| collection | DOAJ |
| description | To investigate the anti-obesity effect of a noni (Morinda citrifolia L.) fruit polysaccharide (NFP) and its potential mechanisms, 24 male C57BL/6J mice were randomly divided into three groups—normal control group, high-fat diet (HFD) group, and NFP-administration group and were gavaged once a day for 12 weeks. The body weights, serum lipid parameters, bile acid (BA)-related proteins, fecal BA, and cecal bacteria of the mice were obtained and analyzed. Results indicate that NFP supplementation (200 mg/kg·bw) reduced the body weight, energy intake, and serum and liver lipids of the HFD mice. Further studies found that NFP activated the hepatic and colonic farnesoid X receptor and increased the excretion of fecal-conjugated BAs, particularly tauro-alpha-muricholic acid and tauro-beta-muricholic acid. In addition, NFP modulated the intestinal microbiota and increased the relative abundance of Lactobacillus in the HFD mice. In conclusion, NFP modulated gut microbiota and improved BA metabolism, which may be the main mechanism behind NFP alleviation of fat accumulation and dyslipidemia in mice under HFD. |
| first_indexed | 2024-04-10T17:24:21Z |
| format | Article |
| id | doaj.art-f0eca1eabbc145deb8e3b6bd218bf860 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T17:24:21Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f0eca1eabbc145deb8e3b6bd218bf8602023-02-05T04:15:33ZengElsevierJournal of Functional Foods1756-46462023-02-01101105408Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolismWenjing Mo0Jiaqi Zou1Ming Wu2Zijun Peng3Wenjiang He4Wenzhi Li5Xiaoyong Wu6School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Food Science, Guangdong Pharmaceutical University, Zhongshan 528453, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, ChinaSchool of Food Science, Guangdong Pharmaceutical University, Zhongshan 528453, ChinaInfinitus (China) Co. Ltd, Xinhui 529156, ChinaInfinitus (China) Co. Ltd, Xinhui 529156, ChinaSchool of Food Science, Guangdong Pharmaceutical University, Zhongshan 528453, China; Corresponding author.To investigate the anti-obesity effect of a noni (Morinda citrifolia L.) fruit polysaccharide (NFP) and its potential mechanisms, 24 male C57BL/6J mice were randomly divided into three groups—normal control group, high-fat diet (HFD) group, and NFP-administration group and were gavaged once a day for 12 weeks. The body weights, serum lipid parameters, bile acid (BA)-related proteins, fecal BA, and cecal bacteria of the mice were obtained and analyzed. Results indicate that NFP supplementation (200 mg/kg·bw) reduced the body weight, energy intake, and serum and liver lipids of the HFD mice. Further studies found that NFP activated the hepatic and colonic farnesoid X receptor and increased the excretion of fecal-conjugated BAs, particularly tauro-alpha-muricholic acid and tauro-beta-muricholic acid. In addition, NFP modulated the intestinal microbiota and increased the relative abundance of Lactobacillus in the HFD mice. In conclusion, NFP modulated gut microbiota and improved BA metabolism, which may be the main mechanism behind NFP alleviation of fat accumulation and dyslipidemia in mice under HFD.http://www.sciencedirect.com/science/article/pii/S1756464623000087NoniMorinda citrifolia L. fruitPolysaccharideHigh-fat dietInduced obesityGut microbiota |
| spellingShingle | Wenjing Mo Jiaqi Zou Ming Wu Zijun Peng Wenjiang He Wenzhi Li Xiaoyong Wu Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism Journal of Functional Foods Noni Morinda citrifolia L. fruit Polysaccharide High-fat diet Induced obesity Gut microbiota |
| title | Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism |
| title_full | Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism |
| title_fullStr | Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism |
| title_full_unstemmed | Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism |
| title_short | Noni (Morinda citrifolia L.) fruit polysaccharide ameliorated high-fat diet-induced obesity by modulating gut microbiota and improving bile acid metabolism |
| title_sort | noni morinda citrifolia l fruit polysaccharide ameliorated high fat diet induced obesity by modulating gut microbiota and improving bile acid metabolism |
| topic | Noni Morinda citrifolia L. fruit Polysaccharide High-fat diet Induced obesity Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623000087 |
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