Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters
Abstract Background To assess the corneal stress-strain index (SSI), which is a marker for material stiffness and corneal biomechanical parameters, in myopic eyes. Methods A total of 1054 myopic patients were included in this study. Corneal visualisation Scheimpflug technology was used to measure th...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01729-x |
| _version_ | 1818116536141873152 |
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| author | Fang Han Mengdi Li Pinghui Wei Jiaonan Ma Vishal Jhanji Yan Wang |
| author_facet | Fang Han Mengdi Li Pinghui Wei Jiaonan Ma Vishal Jhanji Yan Wang |
| author_sort | Fang Han |
| collection | DOAJ |
| description | Abstract Background To assess the corneal stress-strain index (SSI), which is a marker for material stiffness and corneal biomechanical parameters, in myopic eyes. Methods A total of 1054 myopic patients were included in this study. Corneal visualisation Scheimpflug technology was used to measure the SSI. Corneal biomechanics were assessed using the first and second applanation times (A1-and A2-times); maximum deflection amplitude (DefAmax); deflection area (HCDefArea); the highest concavity peak distance (HC-PD), time (HC-time), and deflection amplitude (HC-DefA); integrated radius (IR); whole eye movement (WEM); stiffness parameter (SP-A1;, biomechanically corrected intraocular pressure (BIOP); and Corvis biomechanical index (CBI). Scheimpflug tomography was used to obtain the mean keratometery (Km) and central corneal thickness (CCT). According to the spherical equivalent (SE) (low myopia: SE ≥ − 3.00D and high myopia: SE ≤ − 6.00D.), the suitable patients were divided into two groups. Results The mean SSI value was 0.854 ± 0.004. The SSI had a positive correlation with A1-time ((r = 0.272), HC-time (r = 0.218), WEM (r = 0.288), SP-A1 (r = 0.316), CBI (r = 0.199), CCT (r = 0.125), bIOP (r = 0.230), and SE (r = 0.313) (all p-values<0.01). The SSI had a negative correlation with HCDefA (r = − 0.721), HCDefArea (r = − 0.665), HC-PD(r = − 0.597), IR (r = − 0.555), DefAmax (r = − 0.564), and Km (r = − 0.103) (all p-values<0.01). There were significant differences in SSI (t = 8.960, p<0.01) and IR (t = − 3.509, p<0.01) between the low and high myopia groups. Conclusions In different grades of myopia, the SSI values were lower in eyes with higher SEs. It indicates that the mechanical strength of the cornea may be compromised in high myopia. The SSI was positively correlated with the spherical equivalent, and it may provide a new way to study the mechanism of myopia. |
| first_indexed | 2024-12-11T04:24:04Z |
| format | Article |
| id | doaj.art-f0f1d963b80c46f6a9c00074a72737d9 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-11T04:24:04Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-f0f1d963b80c46f6a9c00074a72737d92022-12-22T01:21:02ZengBMCBMC Ophthalmology1471-24152020-11-012011810.1186/s12886-020-01729-xEffect of biomechanical properties on myopia: a study of new corneal biomechanical parametersFang Han0Mengdi Li1Pinghui Wei2Jiaonan Ma3Vishal Jhanji4Yan Wang5Clinical College of Ophthalmology, Tianjin Medical UniversityClinical College of Ophthalmology, Tianjin Medical UniversityClinical College of Ophthalmology, Tianjin Medical UniversityClinical College of Ophthalmology, Tianjin Medical UniversityUPMC Eye Center, University of Pittsburgh School of MedicineClinical College of Ophthalmology, Tianjin Medical UniversityAbstract Background To assess the corneal stress-strain index (SSI), which is a marker for material stiffness and corneal biomechanical parameters, in myopic eyes. Methods A total of 1054 myopic patients were included in this study. Corneal visualisation Scheimpflug technology was used to measure the SSI. Corneal biomechanics were assessed using the first and second applanation times (A1-and A2-times); maximum deflection amplitude (DefAmax); deflection area (HCDefArea); the highest concavity peak distance (HC-PD), time (HC-time), and deflection amplitude (HC-DefA); integrated radius (IR); whole eye movement (WEM); stiffness parameter (SP-A1;, biomechanically corrected intraocular pressure (BIOP); and Corvis biomechanical index (CBI). Scheimpflug tomography was used to obtain the mean keratometery (Km) and central corneal thickness (CCT). According to the spherical equivalent (SE) (low myopia: SE ≥ − 3.00D and high myopia: SE ≤ − 6.00D.), the suitable patients were divided into two groups. Results The mean SSI value was 0.854 ± 0.004. The SSI had a positive correlation with A1-time ((r = 0.272), HC-time (r = 0.218), WEM (r = 0.288), SP-A1 (r = 0.316), CBI (r = 0.199), CCT (r = 0.125), bIOP (r = 0.230), and SE (r = 0.313) (all p-values<0.01). The SSI had a negative correlation with HCDefA (r = − 0.721), HCDefArea (r = − 0.665), HC-PD(r = − 0.597), IR (r = − 0.555), DefAmax (r = − 0.564), and Km (r = − 0.103) (all p-values<0.01). There were significant differences in SSI (t = 8.960, p<0.01) and IR (t = − 3.509, p<0.01) between the low and high myopia groups. Conclusions In different grades of myopia, the SSI values were lower in eyes with higher SEs. It indicates that the mechanical strength of the cornea may be compromised in high myopia. The SSI was positively correlated with the spherical equivalent, and it may provide a new way to study the mechanism of myopia.http://link.springer.com/article/10.1186/s12886-020-01729-xCorneal stress-strain indexMyopiaCorneal biomechanics |
| spellingShingle | Fang Han Mengdi Li Pinghui Wei Jiaonan Ma Vishal Jhanji Yan Wang Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters BMC Ophthalmology Corneal stress-strain index Myopia Corneal biomechanics |
| title | Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters |
| title_full | Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters |
| title_fullStr | Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters |
| title_full_unstemmed | Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters |
| title_short | Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters |
| title_sort | effect of biomechanical properties on myopia a study of new corneal biomechanical parameters |
| topic | Corneal stress-strain index Myopia Corneal biomechanics |
| url | http://link.springer.com/article/10.1186/s12886-020-01729-x |
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