Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation
Deep brain stimulation (DBS) is an effective treatment for dyskinesia in patients with Parkinson’s disease (PD), among which the therapeutic targets commonly used include the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Levodopa-induced dyskinesia (LID) is one of the common moto...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/8/1054 |
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| author | Fangang Meng Shanshan Cen Zhiqiang Yi Weiguo Li Guoen Cai Feng Wang Stephan S. Quintin Grace E. Hey Jairo S. Hernandez Chunlei Han Shiying Fan Yuan Gao Zimu Song Junfei Yi Kailiang Wang Liangwen Zhang Adolfo Ramirez-Zamora Jianguo Zhang |
| author_facet | Fangang Meng Shanshan Cen Zhiqiang Yi Weiguo Li Guoen Cai Feng Wang Stephan S. Quintin Grace E. Hey Jairo S. Hernandez Chunlei Han Shiying Fan Yuan Gao Zimu Song Junfei Yi Kailiang Wang Liangwen Zhang Adolfo Ramirez-Zamora Jianguo Zhang |
| author_sort | Fangang Meng |
| collection | DOAJ |
| description | Deep brain stimulation (DBS) is an effective treatment for dyskinesia in patients with Parkinson’s disease (PD), among which the therapeutic targets commonly used include the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Levodopa-induced dyskinesia (LID) is one of the common motor complications arising in PD patients on chronic treatment with levodopa. In this article, we retrospectively evaluated the outcomes of LID with the Unified Dyskinesia Rating Scale (UDysRS) in patients who underwent DBS in multiple centers with a GPi or an STN target. Meanwhile, the Med off MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS-Ⅲ) and the levodopa equivalent daily dose (LEDD) were also observed as secondary indicators. PD patients with a GPi target showed a more significant improvement in the UDysRS compared with an STN target (92.9 ± 16.7% vs. 66.0 ± 33.6%, <i>p <</i> 0.0001). Both the GPi and the STN showed similar improvement in Med off UPDRS-III scores (49.8 ± 22.6% vs. 52.3 ± 29.5%, <i>p =</i> 0.5458). However, the LEDD was obviously reduced with the STN target compared with the GPi target (44.6 ± 28.1% vs. 12.2 ± 45.8%, <i>p =</i> 0.006). |
| first_indexed | 2024-03-09T09:59:59Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T09:59:59Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f0f38875593b4a7eb762cd14354774432023-12-01T23:31:11ZengMDPI AGBrain Sciences2076-34252022-08-01128105410.3390/brainsci12081054Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain StimulationFangang Meng0Shanshan Cen1Zhiqiang Yi2Weiguo Li3Guoen Cai4Feng Wang5Stephan S. Quintin6Grace E. Hey7Jairo S. Hernandez8Chunlei Han9Shiying Fan10Yuan Gao11Zimu Song12Junfei Yi13Kailiang Wang14Liangwen Zhang15Adolfo Ramirez-Zamora16Jianguo Zhang17Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, ChinaDepartment of Neurology, Xuanwu Hospital, Beijing 100053, ChinaDepartment of Neurosurgery, Peking University First Hospital, Beijing 100034, ChinaDepartment of Neurosurgery, QiLu Hospital of Shandong University, Jinan 250012, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaDepartment of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Neurology, Fixel Center for Neurological Diseases, Program in Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32607, USADepartment of Neurology, Fixel Center for Neurological Diseases, Program in Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32607, USADepartment of Neurology, Fixel Center for Neurological Diseases, Program in Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32607, USADepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaBeijing Neurosurgical Institute, Capital Medical University, Beijing 100070, ChinaDepartments of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Neurosurgery, QiLu Hospital of Shandong University, Jinan 250012, ChinaBeijing Neurosurgical Institute, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, ChinaDepartment of Neurology, Fixel Center for Neurological Diseases, Program in Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL 32607, USADepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDeep brain stimulation (DBS) is an effective treatment for dyskinesia in patients with Parkinson’s disease (PD), among which the therapeutic targets commonly used include the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Levodopa-induced dyskinesia (LID) is one of the common motor complications arising in PD patients on chronic treatment with levodopa. In this article, we retrospectively evaluated the outcomes of LID with the Unified Dyskinesia Rating Scale (UDysRS) in patients who underwent DBS in multiple centers with a GPi or an STN target. Meanwhile, the Med off MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS-Ⅲ) and the levodopa equivalent daily dose (LEDD) were also observed as secondary indicators. PD patients with a GPi target showed a more significant improvement in the UDysRS compared with an STN target (92.9 ± 16.7% vs. 66.0 ± 33.6%, <i>p <</i> 0.0001). Both the GPi and the STN showed similar improvement in Med off UPDRS-III scores (49.8 ± 22.6% vs. 52.3 ± 29.5%, <i>p =</i> 0.5458). However, the LEDD was obviously reduced with the STN target compared with the GPi target (44.6 ± 28.1% vs. 12.2 ± 45.8%, <i>p =</i> 0.006).https://www.mdpi.com/2076-3425/12/8/1054Parkinson’s diseaselevodopa-induced dyskinesiadeep brain stimulationUnified Dyskinesia Rating Scalelevodopa equivalent daily dose |
| spellingShingle | Fangang Meng Shanshan Cen Zhiqiang Yi Weiguo Li Guoen Cai Feng Wang Stephan S. Quintin Grace E. Hey Jairo S. Hernandez Chunlei Han Shiying Fan Yuan Gao Zimu Song Junfei Yi Kailiang Wang Liangwen Zhang Adolfo Ramirez-Zamora Jianguo Zhang Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation Brain Sciences Parkinson’s disease levodopa-induced dyskinesia deep brain stimulation Unified Dyskinesia Rating Scale levodopa equivalent daily dose |
| title | Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation |
| title_full | Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation |
| title_fullStr | Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation |
| title_full_unstemmed | Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation |
| title_short | Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation |
| title_sort | retrospective multicenter study on outcome measurement for dyskinesia improvement in parkinson s disease patients with pallidal and subthalamic nucleus deep brain stimulation |
| topic | Parkinson’s disease levodopa-induced dyskinesia deep brain stimulation Unified Dyskinesia Rating Scale levodopa equivalent daily dose |
| url | https://www.mdpi.com/2076-3425/12/8/1054 |
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