Post-acute sequelae of COVID-19: A metabolic perspective
The SARS-CoV-2 pandemic continues to rage around the world. At the same time, despite strong public health measures and high vaccination rates in some countries, a post-COVID-19 syndrome has emerged which lacks a clear definition, prevalence, or etiology. However, fatigue, dyspnea, brain fog, and la...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/78200 |
| _version_ | 1811200604774596608 |
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| author | Philipp E Scherer John P Kirwan Clifford J Rosen |
| author_facet | Philipp E Scherer John P Kirwan Clifford J Rosen |
| author_sort | Philipp E Scherer |
| collection | DOAJ |
| description | The SARS-CoV-2 pandemic continues to rage around the world. At the same time, despite strong public health measures and high vaccination rates in some countries, a post-COVID-19 syndrome has emerged which lacks a clear definition, prevalence, or etiology. However, fatigue, dyspnea, brain fog, and lack of smell and/or taste are often characteristic of patients with this syndrome. These are evident more than a month after infection, and are labeled as Post-Acute Sequelae of CoV-2 (PASC) or commonly referred to as long-COVID. Metabolic dysfunction (i.e., obesity, insulin resistance, and diabetes mellitus) is a predisposing risk factor for severe acute COVID-19, and there is emerging evidence that this factor plus a chronic inflammatory state may predispose to PASC. In this article, we explore the potential pathogenic metabolic mechanisms that could underly both severe acute COVID-19 and PASC, and then consider how these might be targeted for future therapeutic approaches. |
| first_indexed | 2024-04-12T02:06:21Z |
| format | Article |
| id | doaj.art-f0f3c7db776546e1a867daa2fa107918 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:06:21Z |
| publishDate | 2022-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f0f3c7db776546e1a867daa2fa1079182022-12-22T03:52:32ZengeLife Sciences Publications LtdeLife2050-084X2022-03-011110.7554/eLife.78200Post-acute sequelae of COVID-19: A metabolic perspectivePhilipp E Scherer0https://orcid.org/0000-0003-0680-3392John P Kirwan1https://orcid.org/0000-0001-7321-9917Clifford J Rosen2https://orcid.org/0000-0003-3436-8199Touchstone Diabetes Center University of Texas Southwestern, Dallas, United StatesPennington Biomedical Research Center, Baton Rouge, United StatesCenter for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, United StatesThe SARS-CoV-2 pandemic continues to rage around the world. At the same time, despite strong public health measures and high vaccination rates in some countries, a post-COVID-19 syndrome has emerged which lacks a clear definition, prevalence, or etiology. However, fatigue, dyspnea, brain fog, and lack of smell and/or taste are often characteristic of patients with this syndrome. These are evident more than a month after infection, and are labeled as Post-Acute Sequelae of CoV-2 (PASC) or commonly referred to as long-COVID. Metabolic dysfunction (i.e., obesity, insulin resistance, and diabetes mellitus) is a predisposing risk factor for severe acute COVID-19, and there is emerging evidence that this factor plus a chronic inflammatory state may predispose to PASC. In this article, we explore the potential pathogenic metabolic mechanisms that could underly both severe acute COVID-19 and PASC, and then consider how these might be targeted for future therapeutic approaches.https://elifesciences.org/articles/78200COVID-19PASCmetabolic dysfunctionobesity |
| spellingShingle | Philipp E Scherer John P Kirwan Clifford J Rosen Post-acute sequelae of COVID-19: A metabolic perspective eLife COVID-19 PASC metabolic dysfunction obesity |
| title | Post-acute sequelae of COVID-19: A metabolic perspective |
| title_full | Post-acute sequelae of COVID-19: A metabolic perspective |
| title_fullStr | Post-acute sequelae of COVID-19: A metabolic perspective |
| title_full_unstemmed | Post-acute sequelae of COVID-19: A metabolic perspective |
| title_short | Post-acute sequelae of COVID-19: A metabolic perspective |
| title_sort | post acute sequelae of covid 19 a metabolic perspective |
| topic | COVID-19 PASC metabolic dysfunction obesity |
| url | https://elifesciences.org/articles/78200 |
| work_keys_str_mv | AT philippescherer postacutesequelaeofcovid19ametabolicperspective AT johnpkirwan postacutesequelaeofcovid19ametabolicperspective AT cliffordjrosen postacutesequelaeofcovid19ametabolicperspective |