Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups
Pertussis incidence has increased in many countries and the disease occurs among all age groups, suggesting the need for booster immunizations through life. In addition to determining the concentration of anti-pertussis toxin (PT) antibodies, the ability of PT neutralizing antibodies (PTNAs) could b...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2053364 |
| _version_ | 1811260703290425344 |
|---|---|
| author | Aapo Knuutila Pauline Versteegen Alex-Mikael Barkoff Pieter van Gageldonk Jussi Mertsola Guy Berbers Qiushui He |
| author_facet | Aapo Knuutila Pauline Versteegen Alex-Mikael Barkoff Pieter van Gageldonk Jussi Mertsola Guy Berbers Qiushui He |
| author_sort | Aapo Knuutila |
| collection | DOAJ |
| description | Pertussis incidence has increased in many countries and the disease occurs among all age groups, suggesting the need for booster immunizations through life. In addition to determining the concentration of anti-pertussis toxin (PT) antibodies, the ability of PT neutralizing antibodies (PTNAs) could be used to assess vaccine responses.Altogether 258 participants [7–10-year-old (N = 73), 11–15-year-old (N = 85), 20–35-year-old (N = 50) and 60–70-year-old (N = 50)] were included. Sera were collected before, one month, and one year after a single dose of a three pertussis component containing acellular pertussis vaccine. The adolescents were primed in childhood either by acellular or whole-cell vaccination. PTNA titres were determined by a Chinese hamster ovary cell assay and anti-PT IgG/IgA antibody concentrations by multiplex immunoassay.In all age groups, a significant increase in levels of PTNAs and anti-PT IgG was observed one month after vaccination and remained at least two-fold higher one year post-booster, in comparison to pre-booster. Young adults had the lowest response. The strongest increase in PTNAs was observed in participants who had ≥10 IU/mL concentration of anti-PT IgG antibodies pre-booster. At pre-booster, whole-cell-primed adolescents had higher PTNAs than acellular-primed peers (p = 0.047). One year post-booster, the Finnish whole-cell-primed adolescents had a higher level of PTNAs than acellular-primed adolescents (p = 0.049), however, this was not observed in Dutch adolescents. In conclusion, PTNAs increased after vaccination in all age groups, and the strongest increase was related to the presence of high pre-booster antibodies. |
| first_indexed | 2024-04-12T18:51:33Z |
| format | Article |
| id | doaj.art-f0f49861f0594fd29518435f373d1840 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-12T18:51:33Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-f0f49861f0594fd29518435f373d18402022-12-22T03:20:28ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512022-12-0111195696310.1080/22221751.2022.2053364Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groupsAapo Knuutila0Pauline Versteegen1Alex-Mikael Barkoff2Pieter van Gageldonk3Jussi Mertsola4Guy Berbers5Qiushui He6Institute of Biomedicine, University of Turku, Turku, FinlandCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsInstitute of Biomedicine, University of Turku, Turku, FinlandCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, FinlandCentre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The NetherlandsInstitute of Biomedicine, University of Turku, Turku, FinlandPertussis incidence has increased in many countries and the disease occurs among all age groups, suggesting the need for booster immunizations through life. In addition to determining the concentration of anti-pertussis toxin (PT) antibodies, the ability of PT neutralizing antibodies (PTNAs) could be used to assess vaccine responses.Altogether 258 participants [7–10-year-old (N = 73), 11–15-year-old (N = 85), 20–35-year-old (N = 50) and 60–70-year-old (N = 50)] were included. Sera were collected before, one month, and one year after a single dose of a three pertussis component containing acellular pertussis vaccine. The adolescents were primed in childhood either by acellular or whole-cell vaccination. PTNA titres were determined by a Chinese hamster ovary cell assay and anti-PT IgG/IgA antibody concentrations by multiplex immunoassay.In all age groups, a significant increase in levels of PTNAs and anti-PT IgG was observed one month after vaccination and remained at least two-fold higher one year post-booster, in comparison to pre-booster. Young adults had the lowest response. The strongest increase in PTNAs was observed in participants who had ≥10 IU/mL concentration of anti-PT IgG antibodies pre-booster. At pre-booster, whole-cell-primed adolescents had higher PTNAs than acellular-primed peers (p = 0.047). One year post-booster, the Finnish whole-cell-primed adolescents had a higher level of PTNAs than acellular-primed adolescents (p = 0.049), however, this was not observed in Dutch adolescents. In conclusion, PTNAs increased after vaccination in all age groups, and the strongest increase was related to the presence of high pre-booster antibodies.https://www.tandfonline.com/doi/10.1080/22221751.2022.2053364Adolescentadultchildneutralizing antibodypertussispertussis toxin |
| spellingShingle | Aapo Knuutila Pauline Versteegen Alex-Mikael Barkoff Pieter van Gageldonk Jussi Mertsola Guy Berbers Qiushui He Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups Emerging Microbes and Infections Adolescent adult child neutralizing antibody pertussis pertussis toxin |
| title | Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups |
| title_full | Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups |
| title_fullStr | Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups |
| title_full_unstemmed | Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups |
| title_short | Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups |
| title_sort | pertussis toxin neutralizing antibody response after an acellular booster vaccination in dutch and finnish participants of different age groups |
| topic | Adolescent adult child neutralizing antibody pertussis pertussis toxin |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2053364 |
| work_keys_str_mv | AT aapoknuutila pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups AT paulineversteegen pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups AT alexmikaelbarkoff pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups AT pietervangageldonk pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups AT jussimertsola pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups AT guyberbers pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups AT qiushuihe pertussistoxinneutralizingantibodyresponseafteranacellularboostervaccinationindutchandfinnishparticipantsofdifferentagegroups |