Scd-1 deficiency promotes the differentiation of CD8+ T effector
The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the fa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1325390/full |
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| author | Yiwei Lin Xushuo Li Haojie Shan Jie Gao Yanying Yang Linlan Jiang Lu Sun Yuwen Chen Fangming Liu Fangming Liu Xiaowei Yu |
| author_facet | Yiwei Lin Xushuo Li Haojie Shan Jie Gao Yanying Yang Linlan Jiang Lu Sun Yuwen Chen Fangming Liu Fangming Liu Xiaowei Yu |
| author_sort | Yiwei Lin |
| collection | DOAJ |
| description | The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the fatty acid de novo synthesis. Scd-1 converts stearic acid (SA) and palmitic acid (PA) to oleic acid (OA) and palmitoleic acid (PO), respectively. In this study, through a series of experiments, we showed that Scd-1 and its resulting compound, OA, have a substantial impact on the transformation of CD8+ naïve T cells into effector T cells. Inactivation of Scd-1 triggers the specialization of CD8+ T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this. A deeper understanding of lipid metabolism in immune cells and its impact on cell function can lead to new therapeutic approaches for controlling the immune response and improving prognosis. |
| first_indexed | 2024-03-08T05:32:33Z |
| format | Article |
| id | doaj.art-f0f6e4f7d4e841fdb5d17bf94309160e |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T05:32:33Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f0f6e4f7d4e841fdb5d17bf94309160e2024-02-06T04:37:21ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-02-011410.3389/fcimb.2024.13253901325390Scd-1 deficiency promotes the differentiation of CD8+ T effectorYiwei Lin0Xushuo Li1Haojie Shan2Jie Gao3Yanying Yang4Linlan Jiang5Lu Sun6Yuwen Chen7Fangming Liu8Fangming Liu9Xiaowei Yu10Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopaedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oncology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Laboratory of Bioactive Small Molecules, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oncology, Zhongshan Hospital, Fudan University, Shanghai, ChinaJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, ChinaJinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Fudan University, Shanghai, ChinaInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopaedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. Stearoyl-CoA desaturase (Scd) is a Δ-9 desaturase, which is a key rate-limiting enzyme for the conversion of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in the fatty acid de novo synthesis. Scd-1 converts stearic acid (SA) and palmitic acid (PA) to oleic acid (OA) and palmitoleic acid (PO), respectively. In this study, through a series of experiments, we showed that Scd-1 and its resulting compound, OA, have a substantial impact on the transformation of CD8+ naïve T cells into effector T cells. Inactivation of Scd-1 triggers the specialization of CD8+ T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this. A deeper understanding of lipid metabolism in immune cells and its impact on cell function can lead to new therapeutic approaches for controlling the immune response and improving prognosis.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1325390/fullmonounsaturated fatty acidstearoyl-CoA desaturaseeffector T cellsdifferentiationinfection |
| spellingShingle | Yiwei Lin Xushuo Li Haojie Shan Jie Gao Yanying Yang Linlan Jiang Lu Sun Yuwen Chen Fangming Liu Fangming Liu Xiaowei Yu Scd-1 deficiency promotes the differentiation of CD8+ T effector Frontiers in Cellular and Infection Microbiology monounsaturated fatty acid stearoyl-CoA desaturase effector T cells differentiation infection |
| title | Scd-1 deficiency promotes the differentiation of CD8+ T effector |
| title_full | Scd-1 deficiency promotes the differentiation of CD8+ T effector |
| title_fullStr | Scd-1 deficiency promotes the differentiation of CD8+ T effector |
| title_full_unstemmed | Scd-1 deficiency promotes the differentiation of CD8+ T effector |
| title_short | Scd-1 deficiency promotes the differentiation of CD8+ T effector |
| title_sort | scd 1 deficiency promotes the differentiation of cd8 t effector |
| topic | monounsaturated fatty acid stearoyl-CoA desaturase effector T cells differentiation infection |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1325390/full |
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