Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent
Bioglass (BG) is a class of biomaterials increasingly approached in biomedical applications, such as in regeneration of hard tissues, due to the properties of bioactivity, osteoinductivity, osteoconductivity, but also the high rate of biodegradation, both in vitro and in vivo. The present paper addr...
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MDPI AG
2021-10-01
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| author | Cristina-Daniela Ghiţulică Andrada-Ioana Damian-Buda Andreia Cucuruz Georgeta Voicu |
| author_facet | Cristina-Daniela Ghiţulică Andrada-Ioana Damian-Buda Andreia Cucuruz Georgeta Voicu |
| author_sort | Cristina-Daniela Ghiţulică |
| collection | DOAJ |
| description | Bioglass (BG) is a class of biomaterials increasingly approached in biomedical applications, such as in regeneration of hard tissues, due to the properties of bioactivity, osteoinductivity, osteoconductivity, but also the high rate of biodegradation, both in vitro and in vivo. The present paper addresses the obtaining of bioglasses from the ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> system by the sol-gel method and the use of a surfactant to ensure a specific surface or high open porosity, starting from S53P4 bioglass (53% SiO<sub>2</sub>, 23% Na<sub>2</sub>O, 20% CaO, 4% P<sub>2</sub>O<sub>5</sub>), also known as BoneAlive<sup>®</sup>. The precursor powders were analyzed from the phase composition point of view by complex thermal analysis and X-ray diffraction, the vitreous powders were assessed from the compositional point of view by X-ray diffraction, morpho-structural by scanning electron microscopy, specific surface area and the pore size dimension by the Brunauer–Emmett–Teller (BET) analysis, dispersion by laser granulometry, and also cell biology and surface mineralization tests were performed by immersion in SBF (simulated body fluid). The system proposed in this paper ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> was successfully obtained by sol-gel method. The results showed the higher interaction between the samples and the SBF medium for samples containing magnesium (M2) and the lowest degree of mineralization after immersion in SBF was noticed for samples containing zinc (M1). The results also prove that by incorporating different ionic species in bioglass composition—Zn<sup>2+</sup> and Mg<sup>2+</sup>, biocompatibility and antibacterial properties will be significantly enhanced. |
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| language | English |
| last_indexed | 2024-03-10T04:03:49Z |
| publishDate | 2021-10-01 |
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| spelling | doaj.art-f0fa44fd552f473682fa7e62d44ae89e2023-11-23T08:27:41ZengMDPI AGGels2310-28612021-10-017418710.3390/gels7040187Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant AgentCristina-Daniela Ghiţulică0Andrada-Ioana Damian-Buda1Andreia Cucuruz2Georgeta Voicu3Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 1–7 Gh. Polizu Street, 011061 Bucharest, RomaniaDepartment of Biomaterials and Medical Devices, Politehnica University of Bucharest, 1–7 Gh. Polizu Street, 011061 Bucharest, RomaniaDepartment of Biomaterials and Medical Devices, Politehnica University of Bucharest, 1–7 Gh. Polizu Street, 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 1–7 Gh. Polizu Street, 011061 Bucharest, RomaniaBioglass (BG) is a class of biomaterials increasingly approached in biomedical applications, such as in regeneration of hard tissues, due to the properties of bioactivity, osteoinductivity, osteoconductivity, but also the high rate of biodegradation, both in vitro and in vivo. The present paper addresses the obtaining of bioglasses from the ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> system by the sol-gel method and the use of a surfactant to ensure a specific surface or high open porosity, starting from S53P4 bioglass (53% SiO<sub>2</sub>, 23% Na<sub>2</sub>O, 20% CaO, 4% P<sub>2</sub>O<sub>5</sub>), also known as BoneAlive<sup>®</sup>. The precursor powders were analyzed from the phase composition point of view by complex thermal analysis and X-ray diffraction, the vitreous powders were assessed from the compositional point of view by X-ray diffraction, morpho-structural by scanning electron microscopy, specific surface area and the pore size dimension by the Brunauer–Emmett–Teller (BET) analysis, dispersion by laser granulometry, and also cell biology and surface mineralization tests were performed by immersion in SBF (simulated body fluid). The system proposed in this paper ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> was successfully obtained by sol-gel method. The results showed the higher interaction between the samples and the SBF medium for samples containing magnesium (M2) and the lowest degree of mineralization after immersion in SBF was noticed for samples containing zinc (M1). The results also prove that by incorporating different ionic species in bioglass composition—Zn<sup>2+</sup> and Mg<sup>2+</sup>, biocompatibility and antibacterial properties will be significantly enhanced.https://www.mdpi.com/2310-2861/7/4/187bioglasssol-gelpore size distributionantibacterial activitybioactivity |
| spellingShingle | Cristina-Daniela Ghiţulică Andrada-Ioana Damian-Buda Andreia Cucuruz Georgeta Voicu Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent Gels bioglass sol-gel pore size distribution antibacterial activity bioactivity |
| title | Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent |
| title_full | Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent |
| title_fullStr | Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent |
| title_full_unstemmed | Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent |
| title_short | Synthesis and Characterization of ZnO(MgO)-CaO-SiO<sub>2</sub>-P<sub>2</sub>O<sub>5</sub> Bioglass Obtained by Sol-Gel Method in Presence of Surfactant Agent |
| title_sort | synthesis and characterization of zno mgo cao sio sub 2 sub p sub 2 sub o sub 5 sub bioglass obtained by sol gel method in presence of surfactant agent |
| topic | bioglass sol-gel pore size distribution antibacterial activity bioactivity |
| url | https://www.mdpi.com/2310-2861/7/4/187 |
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