Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro
Vaccination against COVID-19 is the main global preventive measure in the fight against SARS-CoV-2. As the COVID-19 vaccine will be administered to billions of individuals worldwide during the pandemic, there exists a reasonable fear of severe adverse reactions requiring constant vigilance and caref...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dnipro State Medical University
2023-06-01
|
| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | https://journals.uran.ua/index.php/2307-0404/article/view/283163 |
| _version_ | 1797786882136866816 |
|---|---|
| author | Ye.M. Dytiatkovska K.Yu. Gashynova Ye.V. Korietskaia M.A. Yevtushenko |
| author_facet | Ye.M. Dytiatkovska K.Yu. Gashynova Ye.V. Korietskaia M.A. Yevtushenko |
| author_sort | Ye.M. Dytiatkovska |
| collection | DOAJ |
| description | Vaccination against COVID-19 is the main global preventive measure in the fight against SARS-CoV-2. As the COVID-19 vaccine will be administered to billions of individuals worldwide during the pandemic, there exists a reasonable fear of severe adverse reactions requiring constant vigilance and careful treatment, particularly in individuals with a history of severe allergy. The aim of our study was to develop and implement an algorithm for the safe vaccination against COVID-19 in patients with pathology associated with hypersensitivity reactions. From January to June 2022, after signing the informed consent, 126 adult patients with relevant diseases in remission were included in a prospective single-center study. Complaints and case histories were collected from all patients, including comorbidity and medications received, anthropometric data were studied, a standard clinical examination was performed, tryptase in venous blood was measured, the level of control was additionally assessed in patients with asthma using the asthma control test and spirography. According to the results of the study, it was proven that vaccination against COVID-19 in patients with pathology associated with hypersensitivity reactions is safe, on condition of prior consultation with an allergist and performing vaccination in a medical institution. The algorithm developed for preparing for vaccination in the mentioned above persons consists of a careful collection of case history; assessment and, in case of absence – achieving control of the underlying disease; analysis and correction of therapy with temporary replacement of medications that are potential cofactors of anaphylaxis; determination of blood tryptase level. For safe vaccination in patients with severe allergic anamnesis, administration of 20 mg of desloratadine before each dose of the vaccine with observation after vaccination within 30 minutes is suggested. |
| first_indexed | 2024-03-13T01:15:07Z |
| format | Article |
| id | doaj.art-f0fb1d3b999f492ea628f336b1cd2942 |
| institution | Directory Open Access Journal |
| issn | 2307-0404 |
| language | English |
| last_indexed | 2024-03-13T01:15:07Z |
| publishDate | 2023-06-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj.art-f0fb1d3b999f492ea628f336b1cd29422023-07-05T12:24:27ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042023-06-01282424910.26641/2307-0404.2023.2.283163321384Vaccination against COVID-19 in patients with allergy: experience of the allergological center in DniproYe.M. Dytiatkovska0https://orcid.org/0000-0001-9007-8634K.Yu. Gashynova1https://orcid.org/0000-0003-2955-9687Ye.V. Korietskaia2https://orcid.org/0000-0003-3891-8813M.A. Yevtushenko3https://orcid.org/0000-0002-8088-5608Dnipro state medical university, Volodymyra Vernadskoho str., 9; Municipal Non-Profit Enterprise «Clinical Hospital of Emergency Medical Care» DCC, Volodymyra Antonovycha str, 65, Dnipro, 49044Dnipro state medical university, Volodymyra Vernadskoho str., 9; Municipal Non-Profit Enterprise «Clinical Hospital of Emergency Medical Care» DCC, Volodymyra Antonovycha str, 65, Dnipro, 49044Dnipro state medical university, Volodymyra Vernadskoho str., 9; Municipal Non-Profit Enterprise «Clinical Hospital of Emergency Medical Care» DCC, Volodymyra Antonovycha str, 65, Dnipro, 49044Municipal Non-Profit Enterprise «Clinical Hospital of Emergency Medical Care» DCC, Volodymyra Antonovycha str, 65, Dnipro, 49006Vaccination against COVID-19 is the main global preventive measure in the fight against SARS-CoV-2. As the COVID-19 vaccine will be administered to billions of individuals worldwide during the pandemic, there exists a reasonable fear of severe adverse reactions requiring constant vigilance and careful treatment, particularly in individuals with a history of severe allergy. The aim of our study was to develop and implement an algorithm for the safe vaccination against COVID-19 in patients with pathology associated with hypersensitivity reactions. From January to June 2022, after signing the informed consent, 126 adult patients with relevant diseases in remission were included in a prospective single-center study. Complaints and case histories were collected from all patients, including comorbidity and medications received, anthropometric data were studied, a standard clinical examination was performed, tryptase in venous blood was measured, the level of control was additionally assessed in patients with asthma using the asthma control test and spirography. According to the results of the study, it was proven that vaccination against COVID-19 in patients with pathology associated with hypersensitivity reactions is safe, on condition of prior consultation with an allergist and performing vaccination in a medical institution. The algorithm developed for preparing for vaccination in the mentioned above persons consists of a careful collection of case history; assessment and, in case of absence – achieving control of the underlying disease; analysis and correction of therapy with temporary replacement of medications that are potential cofactors of anaphylaxis; determination of blood tryptase level. For safe vaccination in patients with severe allergic anamnesis, administration of 20 mg of desloratadine before each dose of the vaccine with observation after vaccination within 30 minutes is suggested.https://journals.uran.ua/index.php/2307-0404/article/view/283163covid-19vaccinationanaphylaxishypersensitivityanphylactogenic substancestryptaseimmunoglobulin ebronchial asthmaurticariaallergic rhinitishay fevermastocytosisatopic dermatitiscomorbidity |
| spellingShingle | Ye.M. Dytiatkovska K.Yu. Gashynova Ye.V. Korietskaia M.A. Yevtushenko Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro Medičnì Perspektivi covid-19 vaccination anaphylaxis hypersensitivity anphylactogenic substances tryptase immunoglobulin e bronchial asthma urticaria allergic rhinitis hay fever mastocytosis atopic dermatitis comorbidity |
| title | Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro |
| title_full | Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro |
| title_fullStr | Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro |
| title_full_unstemmed | Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro |
| title_short | Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro |
| title_sort | vaccination against covid 19 in patients with allergy experience of the allergological center in dnipro |
| topic | covid-19 vaccination anaphylaxis hypersensitivity anphylactogenic substances tryptase immunoglobulin e bronchial asthma urticaria allergic rhinitis hay fever mastocytosis atopic dermatitis comorbidity |
| url | https://journals.uran.ua/index.php/2307-0404/article/view/283163 |
| work_keys_str_mv | AT yemdytiatkovska vaccinationagainstcovid19inpatientswithallergyexperienceoftheallergologicalcenterindnipro AT kyugashynova vaccinationagainstcovid19inpatientswithallergyexperienceoftheallergologicalcenterindnipro AT yevkorietskaia vaccinationagainstcovid19inpatientswithallergyexperienceoftheallergologicalcenterindnipro AT mayevtushenko vaccinationagainstcovid19inpatientswithallergyexperienceoftheallergologicalcenterindnipro |