β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease.
The objective of this study was to assess the effects of oral ingestion of β-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus was induced...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4546386?pdf=render |
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| author | Viviam de Oliveira Silva Raquel Vieira Lobato Eric Francelino Andrade Cristina Gomes de Macedo Juliana Trindade Clemente Napimoga Marcelo Henrique Napimoga Michel Reis Messora Ramiro Mendonça Murata Luciano José Pereira |
| author_facet | Viviam de Oliveira Silva Raquel Vieira Lobato Eric Francelino Andrade Cristina Gomes de Macedo Juliana Trindade Clemente Napimoga Marcelo Henrique Napimoga Michel Reis Messora Ramiro Mendonça Murata Luciano José Pereira |
| author_sort | Viviam de Oliveira Silva |
| collection | DOAJ |
| description | The objective of this study was to assess the effects of oral ingestion of β-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus was induced in 48 Wistar rats by intraperitoneal injection of streptozotocin (80 mg/kg). After confirming the diabetes diagnosis, the animals were treated with β-glucans (by gavage) for 28 days. On the 14th day of this period, periodontal disease was induced using a ligature protocol. β-glucans reduced the amount of alveolar bone loss in animals with periodontal disease in both the diabetic and non-diabetic groups (p < 0.05). β-glucans reduced blood glucose, cholesterol and triacylglycerol levels in diabetic animals, both with and without periodontal disease (p < 0.05). Furthermore, treatment with β-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p < 0.05). It was concluded that treatment with β-glucans has beneficial metabolic and periodontal effects in diabetic rats with periodontal disease. |
| first_indexed | 2024-12-21T22:36:19Z |
| format | Article |
| id | doaj.art-f0fcdb8a7c71494ca9e4c625b4120a50 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T22:36:19Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f0fcdb8a7c71494ca9e4c625b4120a502022-12-21T18:47:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013474210.1371/journal.pone.0134742β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease.Viviam de Oliveira SilvaRaquel Vieira LobatoEric Francelino AndradeCristina Gomes de MacedoJuliana Trindade Clemente NapimogaMarcelo Henrique NapimogaMichel Reis MessoraRamiro Mendonça MurataLuciano José PereiraThe objective of this study was to assess the effects of oral ingestion of β-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus was induced in 48 Wistar rats by intraperitoneal injection of streptozotocin (80 mg/kg). After confirming the diabetes diagnosis, the animals were treated with β-glucans (by gavage) for 28 days. On the 14th day of this period, periodontal disease was induced using a ligature protocol. β-glucans reduced the amount of alveolar bone loss in animals with periodontal disease in both the diabetic and non-diabetic groups (p < 0.05). β-glucans reduced blood glucose, cholesterol and triacylglycerol levels in diabetic animals, both with and without periodontal disease (p < 0.05). Furthermore, treatment with β-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p < 0.05). It was concluded that treatment with β-glucans has beneficial metabolic and periodontal effects in diabetic rats with periodontal disease.http://europepmc.org/articles/PMC4546386?pdf=render |
| spellingShingle | Viviam de Oliveira Silva Raquel Vieira Lobato Eric Francelino Andrade Cristina Gomes de Macedo Juliana Trindade Clemente Napimoga Marcelo Henrique Napimoga Michel Reis Messora Ramiro Mendonça Murata Luciano José Pereira β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. PLoS ONE |
| title | β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. |
| title_full | β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. |
| title_fullStr | β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. |
| title_full_unstemmed | β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. |
| title_short | β-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. |
| title_sort | β glucans saccharomyces cereviseae reduce glucose levels and attenuate alveolar bone loss in diabetic rats with periodontal disease |
| url | http://europepmc.org/articles/PMC4546386?pdf=render |
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