Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens
Summary: In chickens, the effect of host genetics on the gut microbiota is not fully understood, and the extent to which the heritable gut microbes affect chicken metabolism and physiology is still an open question. Here, we explored the interactions among chicken genetics, the cecal microbiota and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222007404 |
| _version_ | 1811243290466451456 |
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| author | Yuqing Feng Dan Liu Yan Liu Xinyue Yang Meihong Zhang Fuxiao Wei Depeng Li Yongfei Hu Yuming Guo |
| author_facet | Yuqing Feng Dan Liu Yan Liu Xinyue Yang Meihong Zhang Fuxiao Wei Depeng Li Yongfei Hu Yuming Guo |
| author_sort | Yuqing Feng |
| collection | DOAJ |
| description | Summary: In chickens, the effect of host genetics on the gut microbiota is not fully understood, and the extent to which the heritable gut microbes affect chicken metabolism and physiology is still an open question. Here, we explored the interactions among chicken genetics, the cecal microbiota and metabolites in breast muscle from ten chicken breeds in China. We found that different chicken breeds displayed distinct cecal microbial community structures and functions, and 15 amplicon sequence variants (ASVs) were significantly associated with host genetics through different genetic loci, such as those related to the intestinal barrier function. We identified five heritable ASVs significantly associated with 53 chicken muscle metabolites, among which the Megamonas probably affected lipid metabolism through the production of propionate. Our study revealed that the chicken genetically associated cecal microbes may have the potential to affect the bird’s physiology and metabolism. |
| first_indexed | 2024-04-12T14:04:53Z |
| format | Article |
| id | doaj.art-f0fd9d31596c453cadd29f54c3e7faaa |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T14:04:53Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-f0fd9d31596c453cadd29f54c3e7faaa2022-12-22T03:30:07ZengElsevieriScience2589-00422022-06-01256104469Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickensYuqing Feng0Dan Liu1Yan Liu2Xinyue Yang3Meihong Zhang4Fuxiao Wei5Depeng Li6Yongfei Hu7Yuming Guo8State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China; Corresponding authorState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China; Corresponding authorSummary: In chickens, the effect of host genetics on the gut microbiota is not fully understood, and the extent to which the heritable gut microbes affect chicken metabolism and physiology is still an open question. Here, we explored the interactions among chicken genetics, the cecal microbiota and metabolites in breast muscle from ten chicken breeds in China. We found that different chicken breeds displayed distinct cecal microbial community structures and functions, and 15 amplicon sequence variants (ASVs) were significantly associated with host genetics through different genetic loci, such as those related to the intestinal barrier function. We identified five heritable ASVs significantly associated with 53 chicken muscle metabolites, among which the Megamonas probably affected lipid metabolism through the production of propionate. Our study revealed that the chicken genetically associated cecal microbes may have the potential to affect the bird’s physiology and metabolism.http://www.sciencedirect.com/science/article/pii/S2589004222007404poultry physiologymicrobiome |
| spellingShingle | Yuqing Feng Dan Liu Yan Liu Xinyue Yang Meihong Zhang Fuxiao Wei Depeng Li Yongfei Hu Yuming Guo Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens iScience poultry physiology microbiome |
| title | Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens |
| title_full | Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens |
| title_fullStr | Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens |
| title_full_unstemmed | Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens |
| title_short | Host-genotype-dependent cecal microbes are linked to breast muscle metabolites in Chinese chickens |
| title_sort | host genotype dependent cecal microbes are linked to breast muscle metabolites in chinese chickens |
| topic | poultry physiology microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222007404 |
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