Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes
Abstract Background Esophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative endoscopic submucosal dissection (ESD). However, recent reports have also shown that ESD with adjuvant chemoradiotherapy (CRT) has promising results....
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| Language: | English |
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BMC
2022-11-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-022-02162-8 |
| _version_ | 1798016862375641088 |
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| author | Gen Suzuki Hideya Yamazaki Norihiro Aibe Koji Masui Takuya Kimoto Shinsuke Nagasawa Shou Watanabe Shou Seri Akito Asato Atsushi Shiozaki Hitoshi Fujiwara Hirotaka Konishi Osamu Dohi Takeshi Ishikawa Hany Elsaleh Kei Yamada |
| author_facet | Gen Suzuki Hideya Yamazaki Norihiro Aibe Koji Masui Takuya Kimoto Shinsuke Nagasawa Shou Watanabe Shou Seri Akito Asato Atsushi Shiozaki Hitoshi Fujiwara Hirotaka Konishi Osamu Dohi Takeshi Ishikawa Hany Elsaleh Kei Yamada |
| author_sort | Gen Suzuki |
| collection | DOAJ |
| description | Abstract Background Esophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative endoscopic submucosal dissection (ESD). However, recent reports have also shown that ESD with adjuvant chemoradiotherapy (CRT) has promising results. This retrospective study aimed to elucidate the efficacy of CRT compared to surgery in patients with SESCC after noncurative ESD. Methods This study retrospectively compared the long-term outcomes of patients who received adjuvant treatment with surgery or CRT after noncurative ESD for SESCC. Results Data were collected from 60 patients who developed SESCC after noncurative ESD, 34 of whom received adjuvant chemoradiotherapy (CRT) and 26 underwent esophagectomy. The median follow-up periods were 46 and 56 months in the CRT and esophagectomy groups, respectively. The median patient age was significantly higher in the CRT group than in the esophagectomy group (69 vs. 65 years, p = 0.0054). CRT was completed in all patients, and the incidence of grade ≥ 3 nonhematologic adverse events was 6%. The overall and disease-free survival did not significantly differ between the two groups. Conclusions CRT following ESD seems a promising nonsurgical strategy for optimizing the selection of therapies for high-risk SESCC and warrant further investigation. |
| first_indexed | 2024-04-11T15:56:21Z |
| format | Article |
| id | doaj.art-f0fdee35e516437aba104ab61a33e317 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-11T15:56:21Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-f0fdee35e516437aba104ab61a33e3172022-12-22T04:15:09ZengBMCRadiation Oncology1748-717X2022-11-011711810.1186/s13014-022-02162-8Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomesGen Suzuki0Hideya Yamazaki1Norihiro Aibe2Koji Masui3Takuya Kimoto4Shinsuke Nagasawa5Shou Watanabe6Shou Seri7Akito Asato8Atsushi Shiozaki9Hitoshi Fujiwara10Hirotaka Konishi11Osamu Dohi12Takeshi Ishikawa13Hany Elsaleh14Kei Yamada15Departments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDigestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDigestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDigestive Surgery, Graduate School of Medical Science, Kyoto Prefectural University of MedicineGastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineGastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Radiation Oncology, The AlfredDepartments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineAbstract Background Esophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative endoscopic submucosal dissection (ESD). However, recent reports have also shown that ESD with adjuvant chemoradiotherapy (CRT) has promising results. This retrospective study aimed to elucidate the efficacy of CRT compared to surgery in patients with SESCC after noncurative ESD. Methods This study retrospectively compared the long-term outcomes of patients who received adjuvant treatment with surgery or CRT after noncurative ESD for SESCC. Results Data were collected from 60 patients who developed SESCC after noncurative ESD, 34 of whom received adjuvant chemoradiotherapy (CRT) and 26 underwent esophagectomy. The median follow-up periods were 46 and 56 months in the CRT and esophagectomy groups, respectively. The median patient age was significantly higher in the CRT group than in the esophagectomy group (69 vs. 65 years, p = 0.0054). CRT was completed in all patients, and the incidence of grade ≥ 3 nonhematologic adverse events was 6%. The overall and disease-free survival did not significantly differ between the two groups. Conclusions CRT following ESD seems a promising nonsurgical strategy for optimizing the selection of therapies for high-risk SESCC and warrant further investigation.https://doi.org/10.1186/s13014-022-02162-8EsophagectomyEsophageal neoplasmsEsophageal squamous cell carcinomaEndoscopic mucosal resectionDisease-free survivalChemoradiotherapy |
| spellingShingle | Gen Suzuki Hideya Yamazaki Norihiro Aibe Koji Masui Takuya Kimoto Shinsuke Nagasawa Shou Watanabe Shou Seri Akito Asato Atsushi Shiozaki Hitoshi Fujiwara Hirotaka Konishi Osamu Dohi Takeshi Ishikawa Hany Elsaleh Kei Yamada Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes Radiation Oncology Esophagectomy Esophageal neoplasms Esophageal squamous cell carcinoma Endoscopic mucosal resection Disease-free survival Chemoradiotherapy |
| title | Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes |
| title_full | Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes |
| title_fullStr | Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes |
| title_full_unstemmed | Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes |
| title_short | Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes |
| title_sort | chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection comparison of long term oncologic outcomes |
| topic | Esophagectomy Esophageal neoplasms Esophageal squamous cell carcinoma Endoscopic mucosal resection Disease-free survival Chemoradiotherapy |
| url | https://doi.org/10.1186/s13014-022-02162-8 |
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