Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications
Chitin is a long-chain polymer of <i>N</i>-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomater...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/24/5961 |
| _version_ | 1797544510717165568 |
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| author | Saravut Satitsri Chatchai Muanprasat |
| author_facet | Saravut Satitsri Chatchai Muanprasat |
| author_sort | Saravut Satitsri |
| collection | DOAJ |
| description | Chitin is a long-chain polymer of <i>N</i>-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of <i>N</i>-acetyl-glucosamine and <span style="font-variant: small-caps;">d</span>-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed. |
| first_indexed | 2024-03-10T14:02:31Z |
| format | Article |
| id | doaj.art-f0fedd952ed74155ae82dd00cf5a1ef6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:02:31Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f0fedd952ed74155ae82dd00cf5a1ef62023-11-21T01:04:41ZengMDPI AGMolecules1420-30492020-12-012524596110.3390/molecules25245961Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical ApplicationsSaravut Satitsri0Chatchai Muanprasat1Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn 10540, ThailandChakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn 10540, ThailandChitin is a long-chain polymer of <i>N</i>-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of <i>N</i>-acetyl-glucosamine and <span style="font-variant: small-caps;">d</span>-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.https://www.mdpi.com/1420-3049/25/24/5961chitinchitosanchitosan oligosaccharide |
| spellingShingle | Saravut Satitsri Chatchai Muanprasat Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications Molecules chitin chitosan chitosan oligosaccharide |
| title | Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications |
| title_full | Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications |
| title_fullStr | Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications |
| title_full_unstemmed | Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications |
| title_short | Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications |
| title_sort | chitin and chitosan derivatives as biomaterial resources for biological and biomedical applications |
| topic | chitin chitosan chitosan oligosaccharide |
| url | https://www.mdpi.com/1420-3049/25/24/5961 |
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