Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice
Previous studies have suggested that changes in the white matter might play an important role in the pathogenic processes of Alzheimer's disease (AD). However, no study has investigated sex differences in these changes. Previous studies found that running exercise could delay both the decline i...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-08-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00243/full |
| _version_ | 1818291859755106304 |
|---|---|
| author | Chun-ni Zhou Chun-ni Zhou Feng-lei Chao Feng-lei Chao Yi Zhang Yi Zhang Lin Jiang Lin Jiang Lei Zhang Lei Zhang Yan-min Luo Yan-min Luo Qian Xiao Qian Xiao Lin-mu Chen Lin-mu Chen Yong Tang Yong Tang |
| author_facet | Chun-ni Zhou Chun-ni Zhou Feng-lei Chao Feng-lei Chao Yi Zhang Yi Zhang Lin Jiang Lin Jiang Lei Zhang Lei Zhang Yan-min Luo Yan-min Luo Qian Xiao Qian Xiao Lin-mu Chen Lin-mu Chen Yong Tang Yong Tang |
| author_sort | Chun-ni Zhou |
| collection | DOAJ |
| description | Previous studies have suggested that changes in the white matter might play an important role in the pathogenic processes of Alzheimer's disease (AD). However, no study has investigated sex differences in these changes. Previous studies found that running exercise could delay both the decline in spatial learning and memory abilities as well as the changes in the white matter during early AD in male mice. However, whether exercise also has an effect on the changes in the white matter in female AD mice remains unknown. To address these questions, 6- and 10-month-old male and female APP/PS1 double transgenic AD mice were used. The 6-month-old male and female APP/PS1 double transgenic AD mice underwent a 4-month running exercise regime. The white matter volume and parameters of the myelinated fibers in the white matter of the 10-month-old exercised and non-exercised male and female AD mice were investigated using electron microscopy and stereological methods. There were no significant differences in the mean escape latencies between the male and female AD mice in the non-exercised groups, but after 4 months of treadmill exercise, the mean escape latencies of the female exercised AD mice had significantly shortened compared with those of the male exercised AD mice. The total white matter volume and most of the parameters of the myelinated fibers of the white matter in the female AD mice were significantly lower than those of the male AD mice. The total length of the myelinated fibers with diameters ranging from 0.6 to 0.7 μm, the axonal diameter of the myelinated fibers and the g-ratio of the myelinated fibers in the white matter of the exercised female AD mice were significantly increased compared with those of the non-exercised female AD mice. There were sex-specific differences in the white matter and myelinated fibers of white matter in the AD mice. Running exercise more effectively delayed the decline in spatial learning and memory abilities and delayed the changes in the myelinated fibers of the white matter in female transgenic mice with early AD than in male transgenic mice. |
| first_indexed | 2024-12-13T02:50:46Z |
| format | Article |
| id | doaj.art-f1005e5633314d81bfd2b0efd2291686 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-13T02:50:46Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f1005e5633314d81bfd2b0efd22916862022-12-22T00:02:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-08-011010.3389/fnagi.2018.00243334431Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD MiceChun-ni Zhou0Chun-ni Zhou1Feng-lei Chao2Feng-lei Chao3Yi Zhang4Yi Zhang5Lin Jiang6Lin Jiang7Lei Zhang8Lei Zhang9Yan-min Luo10Yan-min Luo11Qian Xiao12Qian Xiao13Lin-mu Chen14Lin-mu Chen15Yong Tang16Yong Tang17Department of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Chongqing Medical University, Chongqing, ChinaLaboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, ChinaPrevious studies have suggested that changes in the white matter might play an important role in the pathogenic processes of Alzheimer's disease (AD). However, no study has investigated sex differences in these changes. Previous studies found that running exercise could delay both the decline in spatial learning and memory abilities as well as the changes in the white matter during early AD in male mice. However, whether exercise also has an effect on the changes in the white matter in female AD mice remains unknown. To address these questions, 6- and 10-month-old male and female APP/PS1 double transgenic AD mice were used. The 6-month-old male and female APP/PS1 double transgenic AD mice underwent a 4-month running exercise regime. The white matter volume and parameters of the myelinated fibers in the white matter of the 10-month-old exercised and non-exercised male and female AD mice were investigated using electron microscopy and stereological methods. There were no significant differences in the mean escape latencies between the male and female AD mice in the non-exercised groups, but after 4 months of treadmill exercise, the mean escape latencies of the female exercised AD mice had significantly shortened compared with those of the male exercised AD mice. The total white matter volume and most of the parameters of the myelinated fibers of the white matter in the female AD mice were significantly lower than those of the male AD mice. The total length of the myelinated fibers with diameters ranging from 0.6 to 0.7 μm, the axonal diameter of the myelinated fibers and the g-ratio of the myelinated fibers in the white matter of the exercised female AD mice were significantly increased compared with those of the non-exercised female AD mice. There were sex-specific differences in the white matter and myelinated fibers of white matter in the AD mice. Running exercise more effectively delayed the decline in spatial learning and memory abilities and delayed the changes in the myelinated fibers of the white matter in female transgenic mice with early AD than in male transgenic mice.https://www.frontiersin.org/article/10.3389/fnagi.2018.00243/fullwhite mattermyelinated fiberstransgenic mouse modelsex differencesAlzheimer's diseaserunning exercise |
| spellingShingle | Chun-ni Zhou Chun-ni Zhou Feng-lei Chao Feng-lei Chao Yi Zhang Yi Zhang Lin Jiang Lin Jiang Lei Zhang Lei Zhang Yan-min Luo Yan-min Luo Qian Xiao Qian Xiao Lin-mu Chen Lin-mu Chen Yong Tang Yong Tang Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice Frontiers in Aging Neuroscience white matter myelinated fibers transgenic mouse model sex differences Alzheimer's disease running exercise |
| title | Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice |
| title_full | Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice |
| title_fullStr | Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice |
| title_full_unstemmed | Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice |
| title_short | Sex Differences in the White Matter and Myelinated Fibers of APP/PS1 Mice and the Effects of Running Exercise on the Sex Differences of AD Mice |
| title_sort | sex differences in the white matter and myelinated fibers of app ps1 mice and the effects of running exercise on the sex differences of ad mice |
| topic | white matter myelinated fibers transgenic mouse model sex differences Alzheimer's disease running exercise |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00243/full |
| work_keys_str_mv | AT chunnizhou sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT chunnizhou sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT fengleichao sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT fengleichao sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT yizhang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT yizhang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT linjiang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT linjiang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT leizhang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT leizhang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT yanminluo sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT yanminluo sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT qianxiao sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT qianxiao sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT linmuchen sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT linmuchen sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT yongtang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice AT yongtang sexdifferencesinthewhitematterandmyelinatedfibersofappps1miceandtheeffectsofrunningexerciseonthesexdifferencesofadmice |