Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy
INTRODUCTION: Sextant prostate biopsy remains the standard technique for the detection of prostate cancer. It is well known that after a diagnosis of small acinar proliferation (ASAP) or high grade prostate intraepithelial neoplasia (HGPIN), the possibility of finding cancer is approximately 40% and...
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| Format: | Article |
| Language: | English |
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Elsevier España
2008-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300009 |
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| author | Katia Ramos Moreira Leite Luiz Heraldo Camara-Lopes José Cury Marcos F. Dall'Oglio Adriana Sañudo Miguel Srougi |
| author_facet | Katia Ramos Moreira Leite Luiz Heraldo Camara-Lopes José Cury Marcos F. Dall'Oglio Adriana Sañudo Miguel Srougi |
| author_sort | Katia Ramos Moreira Leite |
| collection | DOAJ |
| description | INTRODUCTION: Sextant prostate biopsy remains the standard technique for the detection of prostate cancer. It is well known that after a diagnosis of small acinar proliferation (ASAP) or high grade prostate intraepithelial neoplasia (HGPIN), the possibility of finding cancer is approximately 40% and 30%, respectively. OBJECTIVE: We aim to analyze follow-up biopsies on patients who initially received a benign diagnosis after exclusion of HGPIN and ASAP. METHODS: From July 2000 to December 2003, 1177 patients were submitted to sextant extended prostate biopsy in our hospital. The mean patient age was 65.5 years old, and the median number of fragments collected at biopsy was 13. HGPIN and ASAP were excluded from our study. We only considered patients who had a diagnosis of benign at the first biopsy and were subjected to rebiopsies up until May 2005 because of a maintained suspicion of cancer. RESULTS: Cancer was initially detected in 524 patients (44.5%), and the diagnosis was benign in 415 (35.3%). Rebiopsy was indicated for 76 of the latter patients (18.3%) because of a persistent suspicion of cancer. Eight cases of adenocarcinoma (10.5%) were detected, six (75%) at the first rebiopsy. Six patients were submitted to radical prostatectomy, and all tumors were considered clinically significant. CONCLUSION: Our data indicate that in extended prostate biopsy, the first biopsy detects more cancer, and the first, second, and third rebiopsies after an initial benign diagnosis succeed in finding cancer in 7.9% (6/55), 5.9% (1/15) and 20% (1/4) of patients, respectively. |
| first_indexed | 2024-12-19T09:12:40Z |
| format | Article |
| id | doaj.art-f100e261ca154de3a29bc450e06f4110 |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-19T09:12:40Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-f100e261ca154de3a29bc450e06f41102022-12-21T20:28:10ZengElsevier EspañaClinics1807-59321980-53222008-01-0163333934210.1590/S1807-59322008000300009Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsyKatia Ramos Moreira LeiteLuiz Heraldo Camara-LopesJosé CuryMarcos F. Dall'OglioAdriana SañudoMiguel SrougiINTRODUCTION: Sextant prostate biopsy remains the standard technique for the detection of prostate cancer. It is well known that after a diagnosis of small acinar proliferation (ASAP) or high grade prostate intraepithelial neoplasia (HGPIN), the possibility of finding cancer is approximately 40% and 30%, respectively. OBJECTIVE: We aim to analyze follow-up biopsies on patients who initially received a benign diagnosis after exclusion of HGPIN and ASAP. METHODS: From July 2000 to December 2003, 1177 patients were submitted to sextant extended prostate biopsy in our hospital. The mean patient age was 65.5 years old, and the median number of fragments collected at biopsy was 13. HGPIN and ASAP were excluded from our study. We only considered patients who had a diagnosis of benign at the first biopsy and were subjected to rebiopsies up until May 2005 because of a maintained suspicion of cancer. RESULTS: Cancer was initially detected in 524 patients (44.5%), and the diagnosis was benign in 415 (35.3%). Rebiopsy was indicated for 76 of the latter patients (18.3%) because of a persistent suspicion of cancer. Eight cases of adenocarcinoma (10.5%) were detected, six (75%) at the first rebiopsy. Six patients were submitted to radical prostatectomy, and all tumors were considered clinically significant. CONCLUSION: Our data indicate that in extended prostate biopsy, the first biopsy detects more cancer, and the first, second, and third rebiopsies after an initial benign diagnosis succeed in finding cancer in 7.9% (6/55), 5.9% (1/15) and 20% (1/4) of patients, respectively.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300009ProstateCancerAdenocarcinomaBiopsyBenignProstatic neoplasms |
| spellingShingle | Katia Ramos Moreira Leite Luiz Heraldo Camara-Lopes José Cury Marcos F. Dall'Oglio Adriana Sañudo Miguel Srougi Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy Clinics Prostate Cancer Adenocarcinoma Biopsy Benign Prostatic neoplasms |
| title | Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy |
| title_full | Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy |
| title_fullStr | Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy |
| title_full_unstemmed | Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy |
| title_short | Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy |
| title_sort | prostate cancer detection at rebiopsy after an initial benign diagnosis results using sextant extended prostate biopsy |
| topic | Prostate Cancer Adenocarcinoma Biopsy Benign Prostatic neoplasms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300009 |
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