Current management of parainfluenza pneumonitis in immunocompromised patients: a review
Ann R FalseyUniversity of Rochester, Rochester General Hospital, Rochester, NY, USAAbstract: Parainfluenza viruses (PIV) are common respiratory viruses that belong to the Paramyxoviridae family. PIV infection can lead to a wide variety of clinical syndromes ranging from mild upper respiratory illnes...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2012-08-01
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| Series: | Infection and Drug Resistance |
| Online Access: | http://www.dovepress.com/current-management-of-parainfluenza-pneumonitis-in-immunocompromised-p-a10645 |
| _version_ | 1818265387843715072 |
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| author | Falsey AR |
| author_facet | Falsey AR |
| author_sort | Falsey AR |
| collection | DOAJ |
| description | Ann R FalseyUniversity of Rochester, Rochester General Hospital, Rochester, NY, USAAbstract: Parainfluenza viruses (PIV) are common respiratory viruses that belong to the Paramyxoviridae family. PIV infection can lead to a wide variety of clinical syndromes ranging from mild upper respiratory illness to severe pneumonia. Severe disease can be seen in elderly or chronically ill persons and may be fatal in persons with compromised immune systems, particularly children with severe combined immunodeficiency disease syndrome and hematopathic stem cell transplant recipients. At present, there are no licensed antiviral agents for the treatment of PIV infection. Aerosolized or systemic ribavirin in combination with intravenous gamma globulin has been reported in small, uncontrolled series and case reports of immunocompromised patients. A number of agents show antiviral activity in vitro and in animals, but none are currently approved for human use.Keywords: parainfluenza virus, antiviral agents, immunocompromised host |
| first_indexed | 2024-12-12T19:50:00Z |
| format | Article |
| id | doaj.art-f10393acb7ed4278aee080a4d1c20dde |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-12T19:50:00Z |
| publishDate | 2012-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f10393acb7ed4278aee080a4d1c20dde2022-12-22T00:13:59ZengDove Medical PressInfection and Drug Resistance1178-69732012-08-012012default121127Current management of parainfluenza pneumonitis in immunocompromised patients: a reviewFalsey ARAnn R FalseyUniversity of Rochester, Rochester General Hospital, Rochester, NY, USAAbstract: Parainfluenza viruses (PIV) are common respiratory viruses that belong to the Paramyxoviridae family. PIV infection can lead to a wide variety of clinical syndromes ranging from mild upper respiratory illness to severe pneumonia. Severe disease can be seen in elderly or chronically ill persons and may be fatal in persons with compromised immune systems, particularly children with severe combined immunodeficiency disease syndrome and hematopathic stem cell transplant recipients. At present, there are no licensed antiviral agents for the treatment of PIV infection. Aerosolized or systemic ribavirin in combination with intravenous gamma globulin has been reported in small, uncontrolled series and case reports of immunocompromised patients. A number of agents show antiviral activity in vitro and in animals, but none are currently approved for human use.Keywords: parainfluenza virus, antiviral agents, immunocompromised hosthttp://www.dovepress.com/current-management-of-parainfluenza-pneumonitis-in-immunocompromised-p-a10645 |
| spellingShingle | Falsey AR Current management of parainfluenza pneumonitis in immunocompromised patients: a review Infection and Drug Resistance |
| title | Current management of parainfluenza pneumonitis in immunocompromised patients: a review |
| title_full | Current management of parainfluenza pneumonitis in immunocompromised patients: a review |
| title_fullStr | Current management of parainfluenza pneumonitis in immunocompromised patients: a review |
| title_full_unstemmed | Current management of parainfluenza pneumonitis in immunocompromised patients: a review |
| title_short | Current management of parainfluenza pneumonitis in immunocompromised patients: a review |
| title_sort | current management of parainfluenza pneumonitis in immunocompromised patients a review |
| url | http://www.dovepress.com/current-management-of-parainfluenza-pneumonitis-in-immunocompromised-p-a10645 |
| work_keys_str_mv | AT falseyar currentmanagementofparainfluenzapneumonitisinimmunocompromisedpatientsareview |