Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement
Purpose: To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement. Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement r...
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| Format: | Article |
| Language: | English |
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Knowledge E
2014-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=423;epage=426;aulast=Zarei-Ghanavati |
| _version_ | 1797991026991824896 |
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| author | Siamak Zarei-Ghanavati Reza Alizadeh Sophie X Deng |
| author_facet | Siamak Zarei-Ghanavati Reza Alizadeh Sophie X Deng |
| author_sort | Siamak Zarei-Ghanavati |
| collection | DOAJ |
| description | Purpose: To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement.
Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement received topical IFNα2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Outcome measures included resolution of the lesion, relief of symptoms, systemic and ocular side effects, and recurrence rate.
Results: Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha-2b. The mean age was 60.2 (range: 52-73) years and mean follow up duration was 10.2 months. Clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. No recurrence of OSSN developed during the follow up period.
Conclusion: Topical recombinant IFNα2b appears to be an effective alternative treatment for OSSN with 360° limbal involvement. This approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents. |
| first_indexed | 2024-04-11T08:45:54Z |
| format | Article |
| id | doaj.art-f10456d1afd8451891ea4447776c8968 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T08:45:54Z |
| publishDate | 2014-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-f10456d1afd8451891ea4447776c89682022-12-22T04:33:58ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-019442342610.4103/2008-322X.150811Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvementSiamak Zarei-GhanavatiReza AlizadehSophie X DengPurpose: To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement. Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement received topical IFNα2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Outcome measures included resolution of the lesion, relief of symptoms, systemic and ocular side effects, and recurrence rate. Results: Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha-2b. The mean age was 60.2 (range: 52-73) years and mean follow up duration was 10.2 months. Clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. No recurrence of OSSN developed during the follow up period. Conclusion: Topical recombinant IFNα2b appears to be an effective alternative treatment for OSSN with 360° limbal involvement. This approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=423;epage=426;aulast=Zarei-GhanavatiConjunctival Intraepithelial Neoplasia; Interferon Alpha-2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia |
| spellingShingle | Siamak Zarei-Ghanavati Reza Alizadeh Sophie X Deng Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement Journal of Ophthalmic & Vision Research Conjunctival Intraepithelial Neoplasia; Interferon Alpha-2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia |
| title | Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
| title_full | Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
| title_fullStr | Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
| title_full_unstemmed | Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
| title_short | Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
| title_sort | topical interferon alpha 2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
| topic | Conjunctival Intraepithelial Neoplasia; Interferon Alpha-2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=423;epage=426;aulast=Zarei-Ghanavati |
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