NK Cell Exhaustion
Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00760/full |
| _version_ | 1818525289756491776 |
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| author | Jiacheng Bi Zhigang Tian Zhigang Tian |
| author_facet | Jiacheng Bi Zhigang Tian Zhigang Tian |
| author_sort | Jiacheng Bi |
| collection | DOAJ |
| description | Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections. |
| first_indexed | 2024-12-11T06:07:28Z |
| format | Article |
| id | doaj.art-f1058c0ea8834cf3a2d2862138cd343d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T06:07:28Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f1058c0ea8834cf3a2d2862138cd343d2022-12-22T01:18:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-06-01810.3389/fimmu.2017.00760278004NK Cell ExhaustionJiacheng Bi0Zhigang Tian1Zhigang Tian2Shenzhen Laboratory of Antibody Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaSchool of Life Sciences and Medical Center, Institute of Immunology, Key Laboratory of Innate Immunity and Chronic Disease of Chinese Academy of Science, University of Science and Technology of China, Hefei, ChinaCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaNatural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00760/fulltumorschronic infectionsimmune evasionimmune checkpointsimmunotherapy |
| spellingShingle | Jiacheng Bi Zhigang Tian Zhigang Tian NK Cell Exhaustion Frontiers in Immunology tumors chronic infections immune evasion immune checkpoints immunotherapy |
| title | NK Cell Exhaustion |
| title_full | NK Cell Exhaustion |
| title_fullStr | NK Cell Exhaustion |
| title_full_unstemmed | NK Cell Exhaustion |
| title_short | NK Cell Exhaustion |
| title_sort | nk cell exhaustion |
| topic | tumors chronic infections immune evasion immune checkpoints immunotherapy |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00760/full |
| work_keys_str_mv | AT jiachengbi nkcellexhaustion AT zhigangtian nkcellexhaustion AT zhigangtian nkcellexhaustion |