The first investigation on differences in the effectiveness of mycophenolate mofetil and azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis
Introduction The non-infectious uveitis, a serious vision-threatening disease is the fourth most common cause of blindness in working population of the developed world. Various antimetabolites are applied in corticosteroid-sparing therapy also in Poland but their efficacy was not compared in our cou...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2020-12-01
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| Series: | Annals of Agricultural and Environmental Medicine |
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| Online Access: | http://www.aaem.pl/The-first-investigation-on-differences-in-the-effectiveness-of-mycophenolate-mofetil,125837,0,2.html |
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| author | Maja Waszczyk-Łączak Monika Łazicka-Gałecka Lidia Chomicz Krzysztof Mucha Leszek Pączek Jacek P. Szaflik |
| author_facet | Maja Waszczyk-Łączak Monika Łazicka-Gałecka Lidia Chomicz Krzysztof Mucha Leszek Pączek Jacek P. Szaflik |
| author_sort | Maja Waszczyk-Łączak |
| collection | DOAJ |
| description | Introduction
The non-infectious uveitis, a serious vision-threatening disease is the fourth most common cause of blindness in working population of the developed world. Various antimetabolites are applied in corticosteroid-sparing therapy also in Poland but their efficacy was not compared in our country. The aim of our study was to compare mycophenolate mofetil and azathioprine in terms of therapeutic effect of the antimetabolites in Polish patients with this disease.
Material and methods
The comparative, retrospective study included data of 61 patients admitted to Independent Public University Eye Hospital between January 2009 and January 2017, treated with antimetabolites for non-infectious uveitis. 31 patients received mycophenolate mofetil, 30 patients – azathioprine. In the assessment of corticosteroid-sparing efficacy, among others changes in visual acuity, the duration of the disease and therapy, incidence of ophthalmologic complications, adverse systemic side effects were determined.
Results
The corticosteroid-sparing therapy was more often effective, and an improvement of visual acuity more frequent in patients treated with mycophenolate mofetil than in these receiving azathioprine (84% patients vs. 60%, and 27% patients vs. 13%, respectively); these differences were statistically significant (p<0.05).
Conclusions
Results of our study showing better therapeutic efficacy when applied mycophenolate mofetil seems promising approach for treatment of non-infectious posterior uveitis and panuveitis. In the first study, there was different duration of the disease before drug administration (10.5 years vs. 7.14 years in the azathioprine and mycophenolate mofetil therapy, respectively, p<0.05) and limited number of patients assessed, thus it is desirable to examine more Polish patients treated with the antimetabolites. |
| first_indexed | 2024-12-13T13:09:16Z |
| format | Article |
| id | doaj.art-f1082453f07b4898b9d115f196b8caea |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-13T13:09:16Z |
| publishDate | 2020-12-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-f1082453f07b4898b9d115f196b8caea2022-12-21T23:44:45ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632020-12-0127464464910.26444/aaem/125837125837The first investigation on differences in the effectiveness of mycophenolate mofetil and azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitisMaja Waszczyk-Łączak0Monika Łazicka-Gałecka1Lidia Chomicz2Krzysztof Mucha3Leszek Pączek4Jacek P. Szaflik5SPKSO Ophthalmic Hospital, Warsaw, PolandSPKSO Ophthalmic Hospital, Warsaw, PolandDepartment of Medical Biology, Medical University, Warsaw, PolandDepartment of Immunology, Transplantology, and Internal Diseases, Medical University, Warsaw, PolandDepartment of Immunology, Transplantology, and Internal Diseases, Medical University, Warsaw, PolandSPKSO Ophthalmic Hospital, Warsaw, PolandIntroduction The non-infectious uveitis, a serious vision-threatening disease is the fourth most common cause of blindness in working population of the developed world. Various antimetabolites are applied in corticosteroid-sparing therapy also in Poland but their efficacy was not compared in our country. The aim of our study was to compare mycophenolate mofetil and azathioprine in terms of therapeutic effect of the antimetabolites in Polish patients with this disease. Material and methods The comparative, retrospective study included data of 61 patients admitted to Independent Public University Eye Hospital between January 2009 and January 2017, treated with antimetabolites for non-infectious uveitis. 31 patients received mycophenolate mofetil, 30 patients – azathioprine. In the assessment of corticosteroid-sparing efficacy, among others changes in visual acuity, the duration of the disease and therapy, incidence of ophthalmologic complications, adverse systemic side effects were determined. Results The corticosteroid-sparing therapy was more often effective, and an improvement of visual acuity more frequent in patients treated with mycophenolate mofetil than in these receiving azathioprine (84% patients vs. 60%, and 27% patients vs. 13%, respectively); these differences were statistically significant (p<0.05). Conclusions Results of our study showing better therapeutic efficacy when applied mycophenolate mofetil seems promising approach for treatment of non-infectious posterior uveitis and panuveitis. In the first study, there was different duration of the disease before drug administration (10.5 years vs. 7.14 years in the azathioprine and mycophenolate mofetil therapy, respectively, p<0.05) and limited number of patients assessed, thus it is desirable to examine more Polish patients treated with the antimetabolites.http://www.aaem.pl/The-first-investigation-on-differences-in-the-effectiveness-of-mycophenolate-mofetil,125837,0,2.htmlnon-infectious uveitisimmunosuppressionmycophenolate mofetilazathioprinepolish patientstherapeutic effectiveness |
| spellingShingle | Maja Waszczyk-Łączak Monika Łazicka-Gałecka Lidia Chomicz Krzysztof Mucha Leszek Pączek Jacek P. Szaflik The first investigation on differences in the effectiveness of mycophenolate mofetil and azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis Annals of Agricultural and Environmental Medicine non-infectious uveitis immunosuppression mycophenolate mofetil azathioprine polish patients therapeutic effectiveness |
| title | The first investigation on differences in the effectiveness of mycophenolate mofetil and
azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis |
| title_full | The first investigation on differences in the effectiveness of mycophenolate mofetil and
azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis |
| title_fullStr | The first investigation on differences in the effectiveness of mycophenolate mofetil and
azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis |
| title_full_unstemmed | The first investigation on differences in the effectiveness of mycophenolate mofetil and
azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis |
| title_short | The first investigation on differences in the effectiveness of mycophenolate mofetil and
azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis |
| title_sort | first investigation on differences in the effectiveness of mycophenolate mofetil and azathioprine antimetabolites determined in polish patients treated for non infectious uveitis |
| topic | non-infectious uveitis immunosuppression mycophenolate mofetil azathioprine polish patients therapeutic effectiveness |
| url | http://www.aaem.pl/The-first-investigation-on-differences-in-the-effectiveness-of-mycophenolate-mofetil,125837,0,2.html |
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