Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events
Abstract Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity‐induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn promotes chronic inflammation. Th17 cells have central roles in many inflamm...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.14037 |
| _version_ | 1797738698222075904 |
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| author | Yoshiro Maezawa Yusuke Endo Satomi Kono Tomohiro Ohno Yuumi Nakamura Naoya Teramoto Ayano Yamaguchi Kazuto Aono Takuya Minamizuka Hisaya Kato Takahiro Ishikawa Masaya Koshizaka Minoru Takemoto Toshinori Nakayama Koutaro Yokote |
| author_facet | Yoshiro Maezawa Yusuke Endo Satomi Kono Tomohiro Ohno Yuumi Nakamura Naoya Teramoto Ayano Yamaguchi Kazuto Aono Takuya Minamizuka Hisaya Kato Takahiro Ishikawa Masaya Koshizaka Minoru Takemoto Toshinori Nakayama Koutaro Yokote |
| author_sort | Yoshiro Maezawa |
| collection | DOAJ |
| description | Abstract Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity‐induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn promotes chronic inflammation. Th17 cells have central roles in many inflammatory diseases, including psoriasis and atherosclerosis; however, whether treatment of obesity attenuates Th17 cells and chronic inflammatory diseases has been unknown. In this study, we found an increase in Th17 cells in a patient with obesity, type 2 diabetes and psoriasis. Furthermore, weight loss with diet and exercise resulted in a decrease in Th17 cells and improvement of psoriasis. This case supports the hypothesis that obesity leads to an increase in Th17 cells and chronic inflammation of the skin and blood vessel walls, thereby promoting psoriasis and atherosclerosis. |
| first_indexed | 2024-03-12T13:47:37Z |
| format | Article |
| id | doaj.art-f10891cbf79a443c918d56299715ba3c |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-03-12T13:47:37Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-f10891cbf79a443c918d56299715ba3c2023-08-23T08:32:22ZengWileyJournal of Diabetes Investigation2040-11162040-11242023-09-011491136113910.1111/jdi.14037Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular eventsYoshiro Maezawa0Yusuke Endo1Satomi Kono2Tomohiro Ohno3Yuumi Nakamura4Naoya Teramoto5Ayano Yamaguchi6Kazuto Aono7Takuya Minamizuka8Hisaya Kato9Takahiro Ishikawa10Masaya Koshizaka11Minoru Takemoto12Toshinori Nakayama13Koutaro Yokote14Department of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanKazusa DNA Research Institute Laboratory of Medical Omics Research Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanCutaneous Immunology, Immunology Frontier Research Center Osaka University Osaka JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanDepartment of Diabetes, Metabolism and Endocrinology International University of Health and Welfare Chiba JapanDepartment of Immunology Chiba University Graduate School of Medicine Chiba JapanDepartment of Endocrinology, Hematology and Gerontology Chiba University Graduate School of Medicine Chiba JapanAbstract Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity‐induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn promotes chronic inflammation. Th17 cells have central roles in many inflammatory diseases, including psoriasis and atherosclerosis; however, whether treatment of obesity attenuates Th17 cells and chronic inflammatory diseases has been unknown. In this study, we found an increase in Th17 cells in a patient with obesity, type 2 diabetes and psoriasis. Furthermore, weight loss with diet and exercise resulted in a decrease in Th17 cells and improvement of psoriasis. This case supports the hypothesis that obesity leads to an increase in Th17 cells and chronic inflammation of the skin and blood vessel walls, thereby promoting psoriasis and atherosclerosis.https://doi.org/10.1111/jdi.14037AtherosclerosisPsoriasisTh17 |
| spellingShingle | Yoshiro Maezawa Yusuke Endo Satomi Kono Tomohiro Ohno Yuumi Nakamura Naoya Teramoto Ayano Yamaguchi Kazuto Aono Takuya Minamizuka Hisaya Kato Takahiro Ishikawa Masaya Koshizaka Minoru Takemoto Toshinori Nakayama Koutaro Yokote Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events Journal of Diabetes Investigation Atherosclerosis Psoriasis Th17 |
| title | Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events |
| title_full | Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events |
| title_fullStr | Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events |
| title_full_unstemmed | Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events |
| title_short | Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events |
| title_sort | weight loss improves inflammation by t helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events |
| topic | Atherosclerosis Psoriasis Th17 |
| url | https://doi.org/10.1111/jdi.14037 |
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