Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety?
<p>Abstract</p> <p>Objective</p> <p>Due to organ shortage, average waiting time for a kidney in Germany is about 4 years after start of dialysis. Number of kidney grafts recovered can only be maintained by accepting older and expanded criteria donors. The aim of this st...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-01-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | http://www.eurjmedres.com/content/15/1/31 |
| _version_ | 1818382150963036160 |
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| author | Heuer M Zeiger A Kaiser GM Mathé Z Goldenberg A Sauerland S Paul A Treckmann JW |
| author_facet | Heuer M Zeiger A Kaiser GM Mathé Z Goldenberg A Sauerland S Paul A Treckmann JW |
| author_sort | Heuer M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>Due to organ shortage, average waiting time for a kidney in Germany is about 4 years after start of dialysis. Number of kidney grafts recovered can only be maintained by accepting older and expanded criteria donors. The aim of this study was to analyse the impact of donor and recipient risk on kidney long-term function.</p> <p>Methods</p> <p>All deceased kidney transplantations were considered. We retrospectively studied 332 patients between 2002 and 2006; divided in 4 groups reflecting donor and recipient risk.</p> <p>Results</p> <p>Non-marginal recipients were less likely to receive a marginal organ (69 of 207, 33%) as compared to marginal recipients, of whom two-thirds received a marginal organ (p < 0.0001). Graft function significantly differed between the groups, but detrimental effect of marginal recipient status on eGFR after 12 months (-6 ml/min/1.73 qm, 95% CI -2 to -9) was clearly smaller than the effect of marginal donor status (-10 ml/min/1.73 qm, 95% CI -7 to -14).</p> <p>Conclusions</p> <p>As we were able to show expanded criteria donor has a far bigger effect on long-term graft function than the "extra risk" recipient. Although there have been attempts to define groups of recipients who should be offered ECD kidneys primarily the discussion is still ongoing.</p> |
| first_indexed | 2024-12-14T02:45:54Z |
| format | Article |
| id | doaj.art-f109c8341893490199978a77f940beda |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-14T02:45:54Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-f109c8341893490199978a77f940beda2022-12-21T23:19:53ZengBMCEuropean Journal of Medical Research2047-783X2010-01-011513110.1186/2047-783X-15-1-31Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety?Heuer MZeiger AKaiser GMMathé ZGoldenberg ASauerland SPaul ATreckmann JW<p>Abstract</p> <p>Objective</p> <p>Due to organ shortage, average waiting time for a kidney in Germany is about 4 years after start of dialysis. Number of kidney grafts recovered can only be maintained by accepting older and expanded criteria donors. The aim of this study was to analyse the impact of donor and recipient risk on kidney long-term function.</p> <p>Methods</p> <p>All deceased kidney transplantations were considered. We retrospectively studied 332 patients between 2002 and 2006; divided in 4 groups reflecting donor and recipient risk.</p> <p>Results</p> <p>Non-marginal recipients were less likely to receive a marginal organ (69 of 207, 33%) as compared to marginal recipients, of whom two-thirds received a marginal organ (p < 0.0001). Graft function significantly differed between the groups, but detrimental effect of marginal recipient status on eGFR after 12 months (-6 ml/min/1.73 qm, 95% CI -2 to -9) was clearly smaller than the effect of marginal donor status (-10 ml/min/1.73 qm, 95% CI -7 to -14).</p> <p>Conclusions</p> <p>As we were able to show expanded criteria donor has a far bigger effect on long-term graft function than the "extra risk" recipient. Although there have been attempts to define groups of recipients who should be offered ECD kidneys primarily the discussion is still ongoing.</p>http://www.eurjmedres.com/content/15/1/31Expanded criteria donorskidney transplantationmarginal donorsmarginal recipientsoutcomeprognosis |
| spellingShingle | Heuer M Zeiger A Kaiser GM Mathé Z Goldenberg A Sauerland S Paul A Treckmann JW Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety? European Journal of Medical Research Expanded criteria donors kidney transplantation marginal donors marginal recipients outcome prognosis |
| title | Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety? |
| title_full | Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety? |
| title_fullStr | Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety? |
| title_full_unstemmed | Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety? |
| title_short | Use of marginal organs in kidney transplantation for marginal recipients: too close to the margins of safety? |
| title_sort | use of marginal organs in kidney transplantation for marginal recipients too close to the margins of safety |
| topic | Expanded criteria donors kidney transplantation marginal donors marginal recipients outcome prognosis |
| url | http://www.eurjmedres.com/content/15/1/31 |
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