Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women
Epstein–Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression of this cancer. Accordingly, our group has recently viewed the presence and gen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00250/full |
| _version_ | 1811206340809326592 |
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| author | Hamda Al-Thawadi Lina Ghabreau Lina Ghabreau Tahar Aboulkassim Amber Yasmeen Semir Vranic Gerald Batist Gerald Batist Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa |
| author_facet | Hamda Al-Thawadi Lina Ghabreau Lina Ghabreau Tahar Aboulkassim Amber Yasmeen Semir Vranic Gerald Batist Gerald Batist Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa |
| author_sort | Hamda Al-Thawadi |
| collection | DOAJ |
| description | Epstein–Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression of this cancer. Accordingly, our group has recently viewed the presence and genotyping distribution of high-risk HPVs in cervical cancer in Syrian women; our data pointed out that HPVs are present in 42/44 samples (95%). Herein, we aim to explore the co-prevalence of EBV and high-risk HPVs in 44 cervical cancer tissues from Syrian women using polymerase chain reaction, immunohistochemistry, and tissue microarray analyses. We found that EBV and high-risk HPVs are co-present in 15/44 (34%) of the samples. However, none of the samples was exclusively EBV-positive. Additionally, we report that the co-expression of LMP1 and E6 genes of EBV and high-risk HPVs, respectively, is associated with poorly differentiated squamous cell carcinomas phenotype; this is accompanied by a strong and diffuse overexpression of Id-1 (93% positivity), which is an important regulator of cell invasion and metastasis. These data imply that EBV and HPVs are co-present in cervical cancer samples in the Middle East area including Syria and their co-presence is associated with a more aggressive cancer phenotype. Future investigations are needed to elucidate the exact role of EBV and HPVs cooperation in cervical carcinogenesis. |
| first_indexed | 2024-04-12T03:45:45Z |
| format | Article |
| id | doaj.art-f10a691c526f40d9aec3c42dbb127d18 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T03:45:45Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f10a691c526f40d9aec3c42dbb127d182022-12-22T03:49:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-07-01810.3389/fonc.2018.00250384732Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian WomenHamda Al-Thawadi0Lina Ghabreau1Lina Ghabreau2Tahar Aboulkassim3Amber Yasmeen4Semir Vranic5Gerald Batist6Gerald Batist7Ala-Eddin Al Moustafa8Ala-Eddin Al Moustafa9Ala-Eddin Al Moustafa10Ala-Eddin Al Moustafa11College of Medicine, Qatar University, Doha, QatarFaculty of Medicine, Pathology Department, University of Aleppo, Aleppo, SyriaSyrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, SyriaSegal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, CanadaSegal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, CanadaCollege of Medicine, Qatar University, Doha, QatarSegal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital, Montreal, QC, CanadaOncology Department, McGill University, Montreal, QC, CanadaCollege of Medicine, Qatar University, Doha, QatarSyrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, SyriaOncology Department, McGill University, Montreal, QC, CanadaCollege of Medicine and Biomedical Research Centre of Qatar University, Doha, QatarEpstein–Barr virus (EBV) has been recently shown to be co-present with high-risk human papillomaviruses (HPVs) in human cervical cancer; thus, these oncoviruses play an important role in the initiation and/or progression of this cancer. Accordingly, our group has recently viewed the presence and genotyping distribution of high-risk HPVs in cervical cancer in Syrian women; our data pointed out that HPVs are present in 42/44 samples (95%). Herein, we aim to explore the co-prevalence of EBV and high-risk HPVs in 44 cervical cancer tissues from Syrian women using polymerase chain reaction, immunohistochemistry, and tissue microarray analyses. We found that EBV and high-risk HPVs are co-present in 15/44 (34%) of the samples. However, none of the samples was exclusively EBV-positive. Additionally, we report that the co-expression of LMP1 and E6 genes of EBV and high-risk HPVs, respectively, is associated with poorly differentiated squamous cell carcinomas phenotype; this is accompanied by a strong and diffuse overexpression of Id-1 (93% positivity), which is an important regulator of cell invasion and metastasis. These data imply that EBV and HPVs are co-present in cervical cancer samples in the Middle East area including Syria and their co-presence is associated with a more aggressive cancer phenotype. Future investigations are needed to elucidate the exact role of EBV and HPVs cooperation in cervical carcinogenesis.https://www.frontiersin.org/article/10.3389/fonc.2018.00250/fullEpstein–Barr virushigh-risk human papillomavirusescervical cancerSyrian womencancer phenotype |
| spellingShingle | Hamda Al-Thawadi Lina Ghabreau Lina Ghabreau Tahar Aboulkassim Amber Yasmeen Semir Vranic Gerald Batist Gerald Batist Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Ala-Eddin Al Moustafa Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women Frontiers in Oncology Epstein–Barr virus high-risk human papillomaviruses cervical cancer Syrian women cancer phenotype |
| title | Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women |
| title_full | Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women |
| title_fullStr | Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women |
| title_full_unstemmed | Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women |
| title_short | Co-Incidence of Epstein–Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women |
| title_sort | co incidence of epstein barr virus and high risk human papillomaviruses in cervical cancer of syrian women |
| topic | Epstein–Barr virus high-risk human papillomaviruses cervical cancer Syrian women cancer phenotype |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00250/full |
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