Can the cGAS-STING Pathway Play a Role in the Dry Eye?
Dry eye is one of the most common ocular surface diseases in the world and seriously affects the quality of life of patients. As an immune-related disease, the mechanism of dry eye has still not been fully elucidated. The cGAS-STING pathway is a recently discovered pathway that plays an important ro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.929230/full |
| _version_ | 1818248638341578752 |
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| author | Weijie Ouyang Weijie Ouyang Weijie Ouyang Weijie Ouyang Weijie Ouyang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu |
| author_facet | Weijie Ouyang Weijie Ouyang Weijie Ouyang Weijie Ouyang Weijie Ouyang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu |
| author_sort | Weijie Ouyang |
| collection | DOAJ |
| description | Dry eye is one of the most common ocular surface diseases in the world and seriously affects the quality of life of patients. As an immune-related disease, the mechanism of dry eye has still not been fully elucidated. The cGAS-STING pathway is a recently discovered pathway that plays an important role in autoimmune and inflammatory diseases by recognizing dsDNA. As an important signal to initiate inflammation, the release of dsDNA is associated with dry eye. Herein, we focused on the pathophysiology of the immune-inflammatory response in the pathogenesis of dry eye, attempted to gain insight into the involvement of dsDNA in the dry eye immune response, and investigated the mechanism of the cGAS-STING pathway involved in the immune-inflammatory response. We further proposed that the cGAS-STING pathway may participate in dry eye as a new mechanism linking dry eye and the immune-inflammatory response, thus providing a new direction for the mechanistic exploration of dry eye. |
| first_indexed | 2024-12-12T15:23:47Z |
| format | Article |
| id | doaj.art-f10cee34ab7e4517a3a0fb0bb32a3031 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T15:23:47Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f10cee34ab7e4517a3a0fb0bb32a30312022-12-22T00:20:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.929230929230Can the cGAS-STING Pathway Play a Role in the Dry Eye?Weijie Ouyang0Weijie Ouyang1Weijie Ouyang2Weijie Ouyang3Weijie Ouyang4Shoubi Wang5Shoubi Wang6Shoubi Wang7Shoubi Wang8Shoubi Wang9Shoubi Wang10Shoubi Wang11Shoubi Wang12Jiaoyue Hu13Jiaoyue Hu14Jiaoyue Hu15Jiaoyue Hu16Jiaoyue Hu17Jiaoyue Hu18Zuguo Liu19Zuguo Liu20Zuguo Liu21Zuguo Liu22Zuguo Liu23Zuguo Liu24Zuguo Liu25Eye Institute of Xiamen University, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, ChinaFujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, ChinaEye Institute of Xiamen University, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, ChinaFujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Endocrinology and Diabetes, Xiamen Diabetes Institute, Xiamen University, Xiamen, ChinaXiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen University, Xiamen, ChinaXiamen Diabetes Prevention and Treatment Center, Xiamen University, Xiamen, ChinaFujian Key Laboratory of Diabetes Translational Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaEye Institute of Xiamen University, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, ChinaFujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, China0Xiamen University Affiliated Xiamen Eye Center, Xiamen, ChinaEye Institute of Xiamen University, Xiamen University, Xiamen, ChinaFujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, ChinaFujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen University, Xiamen, China0Xiamen University Affiliated Xiamen Eye Center, Xiamen, China1Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, ChinaDry eye is one of the most common ocular surface diseases in the world and seriously affects the quality of life of patients. As an immune-related disease, the mechanism of dry eye has still not been fully elucidated. The cGAS-STING pathway is a recently discovered pathway that plays an important role in autoimmune and inflammatory diseases by recognizing dsDNA. As an important signal to initiate inflammation, the release of dsDNA is associated with dry eye. Herein, we focused on the pathophysiology of the immune-inflammatory response in the pathogenesis of dry eye, attempted to gain insight into the involvement of dsDNA in the dry eye immune response, and investigated the mechanism of the cGAS-STING pathway involved in the immune-inflammatory response. We further proposed that the cGAS-STING pathway may participate in dry eye as a new mechanism linking dry eye and the immune-inflammatory response, thus providing a new direction for the mechanistic exploration of dry eye.https://www.frontiersin.org/articles/10.3389/fimmu.2022.929230/fullcGAS-STING pathwaydry eyedsDNAinflammationinnate immunity |
| spellingShingle | Weijie Ouyang Weijie Ouyang Weijie Ouyang Weijie Ouyang Weijie Ouyang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Shoubi Wang Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Jiaoyue Hu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Zuguo Liu Can the cGAS-STING Pathway Play a Role in the Dry Eye? Frontiers in Immunology cGAS-STING pathway dry eye dsDNA inflammation innate immunity |
| title | Can the cGAS-STING Pathway Play a Role in the Dry Eye? |
| title_full | Can the cGAS-STING Pathway Play a Role in the Dry Eye? |
| title_fullStr | Can the cGAS-STING Pathway Play a Role in the Dry Eye? |
| title_full_unstemmed | Can the cGAS-STING Pathway Play a Role in the Dry Eye? |
| title_short | Can the cGAS-STING Pathway Play a Role in the Dry Eye? |
| title_sort | can the cgas sting pathway play a role in the dry eye |
| topic | cGAS-STING pathway dry eye dsDNA inflammation innate immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.929230/full |
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