HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW
BACKGROUND Amyloidosis is a disorder of protein metabolism that leads to extracellular deposition ofinsoluble proteinaceous material. Clinically important are amyloidosis AL and AA. Primaryor AL form is associated with immunocyte dyscrasia, multiple myeloma, macroglobulinemiaor monoclonal gammopathy...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2008-02-01
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| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/460 |
| _version_ | 1811277537107509248 |
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| author | Maša Knehtl Davorin Ćeranić Dejan Urlep Ivana Glumbić Rajko Kavalar Marjan Skalicky Pavel Skok |
| author_facet | Maša Knehtl Davorin Ćeranić Dejan Urlep Ivana Glumbić Rajko Kavalar Marjan Skalicky Pavel Skok |
| author_sort | Maša Knehtl |
| collection | DOAJ |
| description | BACKGROUND
Amyloidosis is a disorder of protein metabolism that leads to extracellular deposition ofinsoluble proteinaceous material. Clinically important are amyloidosis AL and AA. Primaryor AL form is associated with immunocyte dyscrasia, multiple myeloma, macroglobulinemiaor monoclonal gammopathy, the precursor protein are immunoglobulin lightchains. Amyloidosis AA or reactive amyloidosis is associated with chronic inflammatorydisease.Patients and The authors are presenting a 52-year old man who was transferred to their department formethods diagnostic proceedings of anaemia and liver disease from the department of orthopaedics,where he was treated for compression fractures of the spine. Unfortunately, during the firsthospitalisation the patient refused liver biopsy. The patient died due to spleenic ruptureand exsanguination into abdominal cavity. At autopsy, amyloidosis was found withamyloid deposits in the liver and other organs. In the article, different forms of this diseasewith grim prognosis are described.
CONCLUSIONS
The authors presented a patient with primary amyloidosis which led to fatal complication.According to the literature, patients with this form of amyloidosis have median survival of1–2 years from establishing the diagnosis |
| first_indexed | 2024-04-13T00:18:29Z |
| format | Article |
| id | doaj.art-f10e97c197824c78891a8f71ed57ea4b |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-04-13T00:18:29Z |
| publishDate | 2008-02-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-f10e97c197824c78891a8f71ed57ea4b2022-12-22T03:10:52ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242008-02-01772352HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEWMaša KnehtlDavorin ĆeranićDejan UrlepIvana GlumbićRajko KavalarMarjan SkalickyPavel SkokBACKGROUND Amyloidosis is a disorder of protein metabolism that leads to extracellular deposition ofinsoluble proteinaceous material. Clinically important are amyloidosis AL and AA. Primaryor AL form is associated with immunocyte dyscrasia, multiple myeloma, macroglobulinemiaor monoclonal gammopathy, the precursor protein are immunoglobulin lightchains. Amyloidosis AA or reactive amyloidosis is associated with chronic inflammatorydisease.Patients and The authors are presenting a 52-year old man who was transferred to their department formethods diagnostic proceedings of anaemia and liver disease from the department of orthopaedics,where he was treated for compression fractures of the spine. Unfortunately, during the firsthospitalisation the patient refused liver biopsy. The patient died due to spleenic ruptureand exsanguination into abdominal cavity. At autopsy, amyloidosis was found withamyloid deposits in the liver and other organs. In the article, different forms of this diseasewith grim prognosis are described. CONCLUSIONS The authors presented a patient with primary amyloidosis which led to fatal complication.According to the literature, patients with this form of amyloidosis have median survival of1–2 years from establishing the diagnosishttp://vestnik.szd.si/index.php/ZdravVest/article/view/460 |
| spellingShingle | Maša Knehtl Davorin Ćeranić Dejan Urlep Ivana Glumbić Rajko Kavalar Marjan Skalicky Pavel Skok HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW Zdravniški Vestnik |
| title | HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW |
| title_full | HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW |
| title_fullStr | HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW |
| title_full_unstemmed | HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW |
| title_short | HEPATIC AMYLOIDOSIS – CASE REPORT AND LITERATURE REVIEW |
| title_sort | hepatic amyloidosis case report and literature review |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/460 |
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