Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers
Diabetes mellitus is often associated with a risk of developing some types of cancer. The association between head and neck cancers and diabetes as well as prognosis and treatment tolerance remains a controversy. Acute toxicities associated with treatment may be amplifi ed by the presence of comorbi...
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| Format: | Article |
| Language: | English |
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Media Med Publicis
2019-06-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-5-1.pdf |
| _version_ | 1818883308559269888 |
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| author | Camil Ciprian Mirestean Ovidiu Nicolae Pagute Simona Cardei Raluca Apostu Calin Buzea Catalina Teaca Ramona Roman Roxana Irina Iancu Dragos Teodor Iancu |
| author_facet | Camil Ciprian Mirestean Ovidiu Nicolae Pagute Simona Cardei Raluca Apostu Calin Buzea Catalina Teaca Ramona Roman Roxana Irina Iancu Dragos Teodor Iancu |
| author_sort | Camil Ciprian Mirestean |
| collection | DOAJ |
| description | Diabetes mellitus is often associated with a risk of developing some types of cancer. The association between head and neck cancers and diabetes as well as prognosis and treatment tolerance remains a controversy. Acute toxicities associated with treatment may be amplifi ed by the presence of comorbidities, including hypertension, diabetes and collagen diseases. Another factor implicated in the treatment tolerance is also the limitation by the presence of hyperglycemia of the corticosteroids dose used for the control of pain and edema associated with chemo-irradiation and for the treatment of thrombocytopenia. The purpose of the study was to evaluate the involvement of diabetes mellitus in the toxicities associated with chemo-radiotherapy treatment in multimodal treated patients for advanced local head and neck cancers. For patients with locally advanced non-metastatic head and neck treated with multimodal (chemo-radiotherapy) acute toxicities (radio-dermitis, radio-mucositis, dysphagia) was analyzed comparatively in patients who associate or not cancer with diabetes. It was also compared if the diagnostic of diabetes influenced the intensity of chemotherapy. Identifying the predictive value of diabetes mellitus for the severity of toxicities in multimodal curative treatment for head and neck cancers can lead to limitation of radiation dose to some radiosensitive anatomical structures in the context of the modern IMRT and VMAT irradiation techniques implementation in clinical practice. |
| first_indexed | 2024-12-19T15:31:35Z |
| format | Article |
| id | doaj.art-f10f088618ce45ae930f93bac60fbdef |
| institution | Directory Open Access Journal |
| issn | 1223-0472 2360-2473 |
| language | English |
| last_indexed | 2024-12-19T15:31:35Z |
| publishDate | 2019-06-01 |
| publisher | Media Med Publicis |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj.art-f10f088618ce45ae930f93bac60fbdef2022-12-21T20:15:44ZengMedia Med PublicisModern Medicine1223-04722360-24732019-06-012626973https://doi.org/10.31689/rmm.2019.26.2.69Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancersCamil Ciprian Mirestean0Ovidiu Nicolae Pagute1Simona Cardei2Raluca Apostu3Calin Buzea4Catalina Teaca5Ramona Roman6Roxana Irina Iancu7Dragos Teodor Iancu8Regional Institute of Oncology, Iasi, RomaniaRegional Institute of Oncology, Iasi, RomaniaEmergency Hospital, Bacau, RomaniaEmergency Hospital, Bacau, RomaniaRegional Institute of Oncology, Iasi, RomaniaRegional Institute of Oncology, Iasi, RomaniaRegional Institute of Oncology, Iasi, Romania„Sf. Spiridon” Emergency Clinical Hospital, Iasi, RomaniaRegional Institute of Oncology, Iasi, RomaniaDiabetes mellitus is often associated with a risk of developing some types of cancer. The association between head and neck cancers and diabetes as well as prognosis and treatment tolerance remains a controversy. Acute toxicities associated with treatment may be amplifi ed by the presence of comorbidities, including hypertension, diabetes and collagen diseases. Another factor implicated in the treatment tolerance is also the limitation by the presence of hyperglycemia of the corticosteroids dose used for the control of pain and edema associated with chemo-irradiation and for the treatment of thrombocytopenia. The purpose of the study was to evaluate the involvement of diabetes mellitus in the toxicities associated with chemo-radiotherapy treatment in multimodal treated patients for advanced local head and neck cancers. For patients with locally advanced non-metastatic head and neck treated with multimodal (chemo-radiotherapy) acute toxicities (radio-dermitis, radio-mucositis, dysphagia) was analyzed comparatively in patients who associate or not cancer with diabetes. It was also compared if the diagnostic of diabetes influenced the intensity of chemotherapy. Identifying the predictive value of diabetes mellitus for the severity of toxicities in multimodal curative treatment for head and neck cancers can lead to limitation of radiation dose to some radiosensitive anatomical structures in the context of the modern IMRT and VMAT irradiation techniques implementation in clinical practice.https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-5-1.pdfdiabeteshead &neck cancerstoxicityradiotherapychemotherapy |
| spellingShingle | Camil Ciprian Mirestean Ovidiu Nicolae Pagute Simona Cardei Raluca Apostu Calin Buzea Catalina Teaca Ramona Roman Roxana Irina Iancu Dragos Teodor Iancu Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers Modern Medicine diabetes head &neck cancers toxicity radiotherapy chemotherapy |
| title | Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers |
| title_full | Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers |
| title_fullStr | Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers |
| title_full_unstemmed | Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers |
| title_short | Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers |
| title_sort | evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers |
| topic | diabetes head &neck cancers toxicity radiotherapy chemotherapy |
| url | https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-5-1.pdf |
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