Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism
A close relationship between fatty acid metabolism and cancer development is well-established. The hydroxyacyl-coenzyme a dehydrogenase (HADH), a key enzyme in fatty acid beta-oxidation, has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-01-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-1-119.pdf |
| _version_ | 1827391339363303424 |
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| author | WU Guojia, ZHAI Shujie, SUN Xiao, HUANG Yiran, LI Yongmei, SUN Li |
| author_facet | WU Guojia, ZHAI Shujie, SUN Xiao, HUANG Yiran, LI Yongmei, SUN Li |
| author_sort | WU Guojia, ZHAI Shujie, SUN Xiao, HUANG Yiran, LI Yongmei, SUN Li |
| collection | DOAJ |
| description | A close relationship between fatty acid metabolism and cancer development is well-established. The hydroxyacyl-coenzyme a dehydrogenase (HADH), a key enzyme in fatty acid beta-oxidation, has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions like acute myeloid leukemia. In cancer cells, HADH not only directly catalyzes fatty acid beta-oxidation but also indirectly influences multiple signaling pathways such as PPAR, TNF-α, JAK-STAT3, PI3K/Akt, IFN-γ, MAPK, and non-canonical Wnt signaling pathways, affecting cancer cell proliferation and migration. HADH shows promise as a potential tumor biomarker for diagnosis, treatment, and prognosis in different cancer types, holding significant clinical value. |
| first_indexed | 2024-03-08T17:09:21Z |
| format | Article |
| id | doaj.art-f10f94de3ed74be0837fd8072b1eccaf |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T17:09:21Z |
| publishDate | 2024-01-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-f10f94de3ed74be0837fd8072b1eccaf2024-01-04T01:09:47ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-01-0144111912310.16352/j.issn.1001-6325.2024.01.0119Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanismWU Guojia, ZHAI Shujie, SUN Xiao, HUANG Yiran, LI Yongmei, SUN Li01. Department of Medical Microbiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300211;;2. Department of Gynaecology and Obstetrics, the Second Hospital of Tianjin Medical University, Tianjin 300070, ChinaA close relationship between fatty acid metabolism and cancer development is well-established. The hydroxyacyl-coenzyme a dehydrogenase (HADH), a key enzyme in fatty acid beta-oxidation, has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions like acute myeloid leukemia. In cancer cells, HADH not only directly catalyzes fatty acid beta-oxidation but also indirectly influences multiple signaling pathways such as PPAR, TNF-α, JAK-STAT3, PI3K/Akt, IFN-γ, MAPK, and non-canonical Wnt signaling pathways, affecting cancer cell proliferation and migration. HADH shows promise as a potential tumor biomarker for diagnosis, treatment, and prognosis in different cancer types, holding significant clinical value.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-1-119.pdfhydroxyacyl-coenzyme a dehydrogenase|lipid metabolism|fatty acid β-oxidation|tumor suppressor gene|tumor marker |
| spellingShingle | WU Guojia, ZHAI Shujie, SUN Xiao, HUANG Yiran, LI Yongmei, SUN Li Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism Jichu yixue yu linchuang hydroxyacyl-coenzyme a dehydrogenase|lipid metabolism|fatty acid β-oxidation|tumor suppressor gene|tumor marker |
| title | Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism |
| title_full | Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism |
| title_fullStr | Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism |
| title_full_unstemmed | Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism |
| title_short | Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism |
| title_sort | progress of the effect of hydroxyacyl coenzyme a dehydrogenase in cancer development and its mechanism |
| topic | hydroxyacyl-coenzyme a dehydrogenase|lipid metabolism|fatty acid β-oxidation|tumor suppressor gene|tumor marker |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-1-119.pdf |
| work_keys_str_mv | AT wuguojiazhaishujiesunxiaohuangyiranliyongmeisunli progressoftheeffectofhydroxyacylcoenzymeadehydrogenaseincancerdevelopmentanditsmechanism |