A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice
Reconstructing the typical analogue of extracellular matrix (ECM) in engineered biomaterials is essential for promoting tissue repair. Here, we report an ECM-mimetic scaffold that successfully accelerated wound healing through enhancing vascularization and regulating inflammation. We prepared an ele...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/9/496 |
| _version_ | 1797518480110518272 |
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| author | Xiaoli Huang Na Guan Qiu Li |
| author_facet | Xiaoli Huang Na Guan Qiu Li |
| author_sort | Xiaoli Huang |
| collection | DOAJ |
| description | Reconstructing the typical analogue of extracellular matrix (ECM) in engineered biomaterials is essential for promoting tissue repair. Here, we report an ECM-mimetic scaffold that successfully accelerated wound healing through enhancing vascularization and regulating inflammation. We prepared an electrospun fiber comprising a brown alga-derived polysaccharide (BAP) and polyvinyl alcohol (PVA). The two polymers in concert exerted the function upon the application of PVA/BAP2 fiber in vivo; it started to reduce the inflammation and promote angiogenesis at the wound site. Our serial in vitro and in vivo tests validated the efficacy of PVA/BAP2 fiber. Particularly, PVA/BAP2 fiber accelerated the repair of a full-thickness skin wound in diabetic mice and induced optimal neo-tissue formation. Generally, our results suggest that, by mimicking the function of ECM, this fiber as an engineered biomaterial can effectively promote the healing efficiency of diabetic wounds. Our investigation may inspire the development of new, effective, and safer marine-derived scaffold for tissue regeneration. |
| first_indexed | 2024-03-10T07:30:28Z |
| format | Article |
| id | doaj.art-f10f9b57e1e74170ba04ef60b27df6f7 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T07:30:28Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f10f9b57e1e74170ba04ef60b27df6f72023-11-22T13:58:40ZengMDPI AGMarine Drugs1660-33972021-08-0119949610.3390/md19090496A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic MiceXiaoli Huang0Na Guan1Qiu Li2Central Laboratory and College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, ChinaCentral Laboratory and College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, ChinaCentral Laboratory and College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, ChinaReconstructing the typical analogue of extracellular matrix (ECM) in engineered biomaterials is essential for promoting tissue repair. Here, we report an ECM-mimetic scaffold that successfully accelerated wound healing through enhancing vascularization and regulating inflammation. We prepared an electrospun fiber comprising a brown alga-derived polysaccharide (BAP) and polyvinyl alcohol (PVA). The two polymers in concert exerted the function upon the application of PVA/BAP2 fiber in vivo; it started to reduce the inflammation and promote angiogenesis at the wound site. Our serial in vitro and in vivo tests validated the efficacy of PVA/BAP2 fiber. Particularly, PVA/BAP2 fiber accelerated the repair of a full-thickness skin wound in diabetic mice and induced optimal neo-tissue formation. Generally, our results suggest that, by mimicking the function of ECM, this fiber as an engineered biomaterial can effectively promote the healing efficiency of diabetic wounds. Our investigation may inspire the development of new, effective, and safer marine-derived scaffold for tissue regeneration.https://www.mdpi.com/1660-3397/19/9/496brown alga polysaccharideinflammatorydiabetic wound healing |
| spellingShingle | Xiaoli Huang Na Guan Qiu Li A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice Marine Drugs brown alga polysaccharide inflammatory diabetic wound healing |
| title | A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice |
| title_full | A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice |
| title_fullStr | A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice |
| title_full_unstemmed | A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice |
| title_short | A Marine-Derived Anti-Inflammatory Scaffold for Accelerating Skin Repair in Diabetic Mice |
| title_sort | marine derived anti inflammatory scaffold for accelerating skin repair in diabetic mice |
| topic | brown alga polysaccharide inflammatory diabetic wound healing |
| url | https://www.mdpi.com/1660-3397/19/9/496 |
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