The Role of NLRP3 Inflammasomes in Trained Immunity
Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis. Trained immunity is the induction of memory in innate immune cells by epigenetic reprogramming due to repeated inflammatory stimuli that alter the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-09-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809210 |
| _version_ | 1797665036765757440 |
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| author | Gilyoung Lee Huijeong Ahn Eunsong Lee Geun-Shik Lee |
| author_facet | Gilyoung Lee Huijeong Ahn Eunsong Lee Geun-Shik Lee |
| author_sort | Gilyoung Lee |
| collection | DOAJ |
| description | Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis. Trained immunity is the induction of memory in innate immune cells by epigenetic reprogramming due to repeated inflammatory stimuli that alter the inflammatory response and increase resistance to infection or disease. Although it is speculated that nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR), and the NLR family pyrin domain containing 3 (NLRP3) inflammasomes respond to various inflammatory stimuli and are associated with trained immunity, the exact relationship is still unclear. This paper aims to introduce data from recent research on the role of inflammasomes in trained immunity through cellular immunometabolic and epigenetic reprogramming. It also suggests a new therapeutic strategy for inflammatory diseases through the complementary regulation of inflammasomes and trained immunity. |
| first_indexed | 2024-03-11T19:38:05Z |
| format | Article |
| id | doaj.art-f110ac1b0b6b4f309ec92167c42aa514 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-11T19:38:05Z |
| publishDate | 2023-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-f110ac1b0b6b4f309ec92167c42aa5142023-10-06T13:06:35ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-09-0128921010.31083/j.fbl2809210S2768-6701(23)01027-4The Role of NLRP3 Inflammasomes in Trained ImmunityGilyoung Lee0Huijeong Ahn1Eunsong Lee2Geun-Shik Lee3College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, 24341 Chuncheon, Republic of KoreaCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, 24341 Chuncheon, Republic of KoreaCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, 24341 Chuncheon, Republic of KoreaCollege of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, 24341 Chuncheon, Republic of KoreaInflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis. Trained immunity is the induction of memory in innate immune cells by epigenetic reprogramming due to repeated inflammatory stimuli that alter the inflammatory response and increase resistance to infection or disease. Although it is speculated that nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR), and the NLR family pyrin domain containing 3 (NLRP3) inflammasomes respond to various inflammatory stimuli and are associated with trained immunity, the exact relationship is still unclear. This paper aims to introduce data from recent research on the role of inflammasomes in trained immunity through cellular immunometabolic and epigenetic reprogramming. It also suggests a new therapeutic strategy for inflammatory diseases through the complementary regulation of inflammasomes and trained immunity.https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809210trained immunitynlrp3inflammasomeinflammatory diseases |
| spellingShingle | Gilyoung Lee Huijeong Ahn Eunsong Lee Geun-Shik Lee The Role of NLRP3 Inflammasomes in Trained Immunity Frontiers in Bioscience-Landmark trained immunity nlrp3 inflammasome inflammatory diseases |
| title | The Role of NLRP3 Inflammasomes in Trained Immunity |
| title_full | The Role of NLRP3 Inflammasomes in Trained Immunity |
| title_fullStr | The Role of NLRP3 Inflammasomes in Trained Immunity |
| title_full_unstemmed | The Role of NLRP3 Inflammasomes in Trained Immunity |
| title_short | The Role of NLRP3 Inflammasomes in Trained Immunity |
| title_sort | role of nlrp3 inflammasomes in trained immunity |
| topic | trained immunity nlrp3 inflammasome inflammatory diseases |
| url | https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809210 |
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