Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located in skeletal muscles, indicating that muscles...

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Bibliographic Details
Main Authors: Sergej Pirkmajer, Katja Bezjak, Urška Matkovič, Klemen Dolinar, Lake Q. Jiang, Katarina Miš, Katarina Gros, Kseniya Milovanova, Katja Perdan Pirkmajer, Tomaž Marš, Leonid Kapilevich, Alexander V. Chibalin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Physiology
Subjects:
Ouabain
marinobufagenin
Na
K-ATPase
cytokines
skeletal muscle
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.566584/full

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