MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways

MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways

Background/Aims: With increased understanding of sepsis, mortality is decreasing. However, there is still a lack of effective therapeutic strategy. The inflammatory response of macrophages is critical during sepsis. Methods: Macrophages were stimulated with LPS. Western blotting and qRT-PCR were use...

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Bibliographic Details
Main Authors: Xiao-Zhi Bai, Ju-Lei Zhang, Yang Liu, Wei Zhang, Xiao-Qiang Li, Ke-Jia Wang, Meng-Yuan Cao, Jia-Ning Zhang, Fu Han, Ji-Hong Shi, Da-Hai  Hu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Inflammation
MicroRNA-138
SIRT1
Macrophage
NF-κB
AKT
Online Access:https://www.karger.com/Article/FullText/492988

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