The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease
With the world’s population ageing, the incidence of Parkinson’s disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/9/4676 |
| _version_ | 1797535949835468800 |
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| author | Katja Badanjak Sonja Fixemer Semra Smajić Alexander Skupin Anne Grünewald |
| author_facet | Katja Badanjak Sonja Fixemer Semra Smajić Alexander Skupin Anne Grünewald |
| author_sort | Katja Badanjak |
| collection | DOAJ |
| description | With the world’s population ageing, the incidence of Parkinson’s disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD. |
| first_indexed | 2024-03-10T11:52:37Z |
| format | Article |
| id | doaj.art-f11408bfe2864403b09fe5120518ab50 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:52:37Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f11408bfe2864403b09fe5120518ab502023-11-21T17:38:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229467610.3390/ijms22094676The Contribution of Microglia to Neuroinflammation in Parkinson’s DiseaseKatja Badanjak0Sonja Fixemer1Semra Smajić2Alexander Skupin3Anne Grünewald4Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Esch-sur-Alzette, LuxembourgLuxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Esch-sur-Alzette, LuxembourgLuxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Esch-sur-Alzette, LuxembourgLuxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Esch-sur-Alzette, LuxembourgLuxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Esch-sur-Alzette, LuxembourgWith the world’s population ageing, the incidence of Parkinson’s disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD.https://www.mdpi.com/1422-0067/22/9/4676neuroinflammationmicrogliabrainneurodegenerationanimal modelsiPSC |
| spellingShingle | Katja Badanjak Sonja Fixemer Semra Smajić Alexander Skupin Anne Grünewald The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease International Journal of Molecular Sciences neuroinflammation microglia brain neurodegeneration animal models iPSC |
| title | The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease |
| title_full | The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease |
| title_fullStr | The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease |
| title_full_unstemmed | The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease |
| title_short | The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease |
| title_sort | contribution of microglia to neuroinflammation in parkinson s disease |
| topic | neuroinflammation microglia brain neurodegeneration animal models iPSC |
| url | https://www.mdpi.com/1422-0067/22/9/4676 |
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