Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children
Abstract Background The Social Responsiveness Scale (SRS) is a 65‐item measure yielding a continuous score capturing autism‐related traits. Scores based on SRS item subsets have been analytically examined but administration of shortened versions has not been evaluated prospectively. Objective The go...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | JCPP Advances |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcv2.12106 |
| _version_ | 1798005864173404160 |
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| author | Kristen Lyall Juliette Rando Bridget Toroni Tobechukwu Ezeh John N. Constantino Lisa A. Croen Brigid Garvin Kate Piselli James Connell Aaron J. Kaat Craig J. Newschaffer program collaborators for Environmental influences on Child Health Outcomes |
| author_facet | Kristen Lyall Juliette Rando Bridget Toroni Tobechukwu Ezeh John N. Constantino Lisa A. Croen Brigid Garvin Kate Piselli James Connell Aaron J. Kaat Craig J. Newschaffer program collaborators for Environmental influences on Child Health Outcomes |
| author_sort | Kristen Lyall |
| collection | DOAJ |
| description | Abstract Background The Social Responsiveness Scale (SRS) is a 65‐item measure yielding a continuous score capturing autism‐related traits. Scores based on SRS item subsets have been analytically examined but administration of shortened versions has not been evaluated prospectively. Objective The goal of this study was to compare psychometric properties of two shortened versions of the SRS to the full 65‐item SRS, in young children from both a clinical and general population setting. Methods Study participants (aged 3–5 years) were drawn from the AJ Drexel Autism Institute clinic (n = 154) and Kaiser Permanente Northern California (n = 201) and block randomized to receive either the 16‐item short SRS, a newly developed computer adaptive testing‐SRS, or the published full‐length SRS. Total scores across the three SRS administration methods were scaled to facilitate comparisons. Scores were plotted to assess distributional properties, while Receiver Operating Characteristic analysis was used to estimate Area Under the Curve (AUC) and address predictive ability. Results Overall, distributional properties of the three administration methods were highly comparable, with shortened measures demonstrating similar ability to capture the range of the distribution and case non‐case separation as the full SRS. In addition, AUC values were high (0.91–0.97) and comparable across the administration methods, though there was evidence of difference in predictive ability across measures for females (AUC for full SRS = 0.99 vs. 0.84 for short). Within individual comparisons of short versus full scores (available only for participants at the general population site) suggested underestimation of actual full SRS scores with the CAT‐SRS. Conclusions Our findings broadly support the construct validity and performance of shortened SRS versions examined here, though the full measure may be needed to more accurately assess traits consistent with ASD diagnosis in females. This work suggests opportunities for collection of ASD‐related phenotype in settings where participant burden or feasibility considerations may have otherwise prohibited such measurement. |
| first_indexed | 2024-04-11T12:45:49Z |
| format | Article |
| id | doaj.art-f114aca1258947068697c1c7f415de1b |
| institution | Directory Open Access Journal |
| issn | 2692-9384 |
| language | English |
| last_indexed | 2024-04-11T12:45:49Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | JCPP Advances |
| spelling | doaj.art-f114aca1258947068697c1c7f415de1b2022-12-22T04:23:21ZengWileyJCPP Advances2692-93842022-12-0124n/an/a10.1002/jcv2.12106Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old childrenKristen Lyall0Juliette Rando1Bridget Toroni2Tobechukwu Ezeh3John N. Constantino4Lisa A. Croen5Brigid Garvin6Kate Piselli7James Connell8Aaron J. Kaat9Craig J. Newschaffer10program collaborators for Environmental influences on Child Health OutcomesAJ Drexel Autism Institute Drexel University Philadelphia Pennsylvania USAAJ Drexel Autism Institute Drexel University Philadelphia Pennsylvania USAAJ Drexel Autism Institute Drexel University Philadelphia Pennsylvania USADepartment of Epidemiology and Biostatistics Dornsife School of Public Health Drexel University Philadelphia Pennsylvania USADepartment of Psychiatry Washington University St. Louis Missouri USADivision of Research Kaiser Permanente Oakland California USAAJ Drexel Autism Institute Drexel University Philadelphia Pennsylvania USAAJ Drexel Autism Institute Drexel University Philadelphia Pennsylvania USASchool of Education Drexel University Philadelphia Pennsylvania USADepartment of Medical Social Sciences Feinberg School of Medicine Northwestern University Chicago Illinois USACollege of Health and Human Development Pennsylvania State University Philadelphia PennsylvaniaPA USAAbstract Background The Social Responsiveness Scale (SRS) is a 65‐item measure yielding a continuous score capturing autism‐related traits. Scores based on SRS item subsets have been analytically examined but administration of shortened versions has not been evaluated prospectively. Objective The goal of this study was to compare psychometric properties of two shortened versions of the SRS to the full 65‐item SRS, in young children from both a clinical and general population setting. Methods Study participants (aged 3–5 years) were drawn from the AJ Drexel Autism Institute clinic (n = 154) and Kaiser Permanente Northern California (n = 201) and block randomized to receive either the 16‐item short SRS, a newly developed computer adaptive testing‐SRS, or the published full‐length SRS. Total scores across the three SRS administration methods were scaled to facilitate comparisons. Scores were plotted to assess distributional properties, while Receiver Operating Characteristic analysis was used to estimate Area Under the Curve (AUC) and address predictive ability. Results Overall, distributional properties of the three administration methods were highly comparable, with shortened measures demonstrating similar ability to capture the range of the distribution and case non‐case separation as the full SRS. In addition, AUC values were high (0.91–0.97) and comparable across the administration methods, though there was evidence of difference in predictive ability across measures for females (AUC for full SRS = 0.99 vs. 0.84 for short). Within individual comparisons of short versus full scores (available only for participants at the general population site) suggested underestimation of actual full SRS scores with the CAT‐SRS. Conclusions Our findings broadly support the construct validity and performance of shortened SRS versions examined here, though the full measure may be needed to more accurately assess traits consistent with ASD diagnosis in females. This work suggests opportunities for collection of ASD‐related phenotype in settings where participant burden or feasibility considerations may have otherwise prohibited such measurement.https://doi.org/10.1002/jcv2.12106autism spectrum disorderquantitative traitsSocial Responsiveness Scalevalidation study |
| spellingShingle | Kristen Lyall Juliette Rando Bridget Toroni Tobechukwu Ezeh John N. Constantino Lisa A. Croen Brigid Garvin Kate Piselli James Connell Aaron J. Kaat Craig J. Newschaffer program collaborators for Environmental influences on Child Health Outcomes Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children JCPP Advances autism spectrum disorder quantitative traits Social Responsiveness Scale validation study |
| title | Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children |
| title_full | Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children |
| title_fullStr | Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children |
| title_full_unstemmed | Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children |
| title_short | Examining shortened versions of the Social Responsiveness Scale for use in autism spectrum disorder prediction and as a quantitative trait measure: Results from a validation study of 3–5 year old children |
| title_sort | examining shortened versions of the social responsiveness scale for use in autism spectrum disorder prediction and as a quantitative trait measure results from a validation study of 3 5 year old children |
| topic | autism spectrum disorder quantitative traits Social Responsiveness Scale validation study |
| url | https://doi.org/10.1002/jcv2.12106 |
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