Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease
Increasing evidence suggests that elevated intracellular levels of reactive oxygen species (ROS) play a significant role in the pathogenesis of many diseases. Increased intracellular levels of ROS can lead to the oxidation of lipids, DNA, and proteins, contributing to cellular damage. Hence, the mai...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023100284 |
| _version_ | 1797383970127609856 |
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| author | Nasrin Mehranfard Maedeh Ghasemi Arezoo Rajabian Legha Ansari |
| author_facet | Nasrin Mehranfard Maedeh Ghasemi Arezoo Rajabian Legha Ansari |
| author_sort | Nasrin Mehranfard |
| collection | DOAJ |
| description | Increasing evidence suggests that elevated intracellular levels of reactive oxygen species (ROS) play a significant role in the pathogenesis of many diseases. Increased intracellular levels of ROS can lead to the oxidation of lipids, DNA, and proteins, contributing to cellular damage. Hence, the maintenance of redox hemostasis is essential. Naringenin (NAR) is a flavonoid included in the flavanones subcategory. Various pharmacological actions have been ascribable to this phytochemical composition, including antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, antiadipogenic, neuro-, and cardio-protective activities. This review focused on the underlying mechanism responsible for the antioxidative stress properties of NAR and its' nanoformulations. Several lines of in vitro and in vivo investigations suggest the effects of NAR and its nanoformulation on their target cells via modulating signaling pathways. These nanoformulations include nanoemulsion, nanocarriers, solid lipid nanoparticles (SLN), and nanomicelle. This review also highlights several beneficial health effects of NAR nanoformulations on human diseases including brain disorders, cancer, rheumatoid arthritis, and small intestine injuries. Employing nanoformulation can improve the pharmacokinetic properties of NAR and consequently efficiency by reducing its limitations, such as low bioavailability. The protective effects of NAR and its’ nanoformulations against oxidative stress may be linked to the modulation of Nrf2-heme oxygenase-1, NO/cGMP/potassium channel, COX-2, NF-κB, AMPK/SIRT3, PI3K/Akt/mTOR, BDNF, NOX, and LOX-1 pathways. Understanding the mechanism behind the protective effects of NAR can facilitate drug development for the treatment of oxidative stress-related disorders. |
| first_indexed | 2024-03-08T21:28:41Z |
| format | Article |
| id | doaj.art-f11534fee7c9472b8d82190febdcf12c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T21:28:41Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f11534fee7c9472b8d82190febdcf12c2023-12-21T07:34:46ZengElsevierHeliyon2405-84402023-12-01912e22820Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and diseaseNasrin Mehranfard0Maedeh Ghasemi1Arezoo Rajabian2Legha Ansari3Nanokadeh Darooee Samen Private Joint Stock Company, Urmia, 5715793731, IranDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranNeuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, IranCellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran; Nanokadeh Darooee Samen Private Joint Stock Company, Urmia, 5715793731, Iran; Corresponding author. Pharmaceutical Nanotechnology, Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Shafa Street, Urmia 57157-89400, Iran.Increasing evidence suggests that elevated intracellular levels of reactive oxygen species (ROS) play a significant role in the pathogenesis of many diseases. Increased intracellular levels of ROS can lead to the oxidation of lipids, DNA, and proteins, contributing to cellular damage. Hence, the maintenance of redox hemostasis is essential. Naringenin (NAR) is a flavonoid included in the flavanones subcategory. Various pharmacological actions have been ascribable to this phytochemical composition, including antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, antiadipogenic, neuro-, and cardio-protective activities. This review focused on the underlying mechanism responsible for the antioxidative stress properties of NAR and its' nanoformulations. Several lines of in vitro and in vivo investigations suggest the effects of NAR and its nanoformulation on their target cells via modulating signaling pathways. These nanoformulations include nanoemulsion, nanocarriers, solid lipid nanoparticles (SLN), and nanomicelle. This review also highlights several beneficial health effects of NAR nanoformulations on human diseases including brain disorders, cancer, rheumatoid arthritis, and small intestine injuries. Employing nanoformulation can improve the pharmacokinetic properties of NAR and consequently efficiency by reducing its limitations, such as low bioavailability. The protective effects of NAR and its’ nanoformulations against oxidative stress may be linked to the modulation of Nrf2-heme oxygenase-1, NO/cGMP/potassium channel, COX-2, NF-κB, AMPK/SIRT3, PI3K/Akt/mTOR, BDNF, NOX, and LOX-1 pathways. Understanding the mechanism behind the protective effects of NAR can facilitate drug development for the treatment of oxidative stress-related disorders.http://www.sciencedirect.com/science/article/pii/S2405844023100284NaringeninNanoformulationNanotechnologyRedox mechanismsOxidative stressAntioxidant |
| spellingShingle | Nasrin Mehranfard Maedeh Ghasemi Arezoo Rajabian Legha Ansari Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease Heliyon Naringenin Nanoformulation Nanotechnology Redox mechanisms Oxidative stress Antioxidant |
| title | Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease |
| title_full | Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease |
| title_fullStr | Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease |
| title_full_unstemmed | Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease |
| title_short | Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease |
| title_sort | protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease |
| topic | Naringenin Nanoformulation Nanotechnology Redox mechanisms Oxidative stress Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023100284 |
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