Effects of Atorvastatin, Amlodipine, and Their Combination on Vascular Dysfunction in Insulin-Resistant Rats

Effects of Atorvastatin, Amlodipine, and Their Combination on Vascular Dysfunction in Insulin-Resistant Rats

Abstract.: Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O2−) generation in the insulin-resistant state. We investigated the effects of atorvastatin, a 3-hydroxyl-3-methylglutaryl co...

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Bibliographic Details
Main Authors:	Tomio Okamura, Masashi Tawa, Ayman Geddawy, Takashi Shimosato, Hirotaka Iwasaki, Haruo Shintaku, Yuichi Yoshida, Masahiro Masada, Kazuya Shinozaki, Takeshi Imamura
Format:	Article
Language:	English
Published:	Elsevier 2014-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786131930221X

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