Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina
Summary: The vertebrate inner retina is driven by photoreceptors whose outputs are already pre-processed; in zebrafish, outer retinal circuits split “color” from “grayscale” information across four cone-photoreceptor types. It remains unclear how the inner retina processes incoming spectral informat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723000669 |
| _version_ | 1811168512780009472 |
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| author | Xinwei Wang Paul A. Roberts Takeshi Yoshimatsu Leon Lagnado Tom Baden |
| author_facet | Xinwei Wang Paul A. Roberts Takeshi Yoshimatsu Leon Lagnado Tom Baden |
| author_sort | Xinwei Wang |
| collection | DOAJ |
| description | Summary: The vertebrate inner retina is driven by photoreceptors whose outputs are already pre-processed; in zebrafish, outer retinal circuits split “color” from “grayscale” information across four cone-photoreceptor types. It remains unclear how the inner retina processes incoming spectral information while also combining cone signals to shape grayscale functions. We address this question by imaging the light-driven responses of amacrine cells (ACs) and bipolar cells (BCs) in larval zebrafish in the presence and pharmacological absence of inner retinal inhibition. We find that ACs enhance opponency in some bipolar cells while at the same time suppressing pre-existing opponency in others, so that, depending on the retinal region, the net change in the number of color-opponent units is essentially zero. To achieve this “dynamic balance,” ACs counteract intrinsic color opponency of BCs via the On channel. Consistent with these observations, Off-stratifying ACs are exclusively achromatic, while all color-opponent ACs stratify in the On sublamina. |
| first_indexed | 2024-04-10T16:27:27Z |
| format | Article |
| id | doaj.art-f115e66dbbee47f19c5b0efcc1c42052 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T16:27:27Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-f115e66dbbee47f19c5b0efcc1c420522023-02-09T04:14:01ZengElsevierCell Reports2211-12472023-02-01422112055Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retinaXinwei Wang0Paul A. Roberts1Takeshi Yoshimatsu2Leon Lagnado3Tom Baden4School of Life Sciences, University of Sussex, Biology Road, Brighton BN1 9QG, UK; Corresponding authorSchool of Life Sciences, University of Sussex, Biology Road, Brighton BN1 9QG, UKSchool of Life Sciences, University of Sussex, Biology Road, Brighton BN1 9QG, UKSchool of Life Sciences, University of Sussex, Biology Road, Brighton BN1 9QG, UK; Corresponding authorSchool of Life Sciences, University of Sussex, Biology Road, Brighton BN1 9QG, UK; Institute of Ophthalmic Research, University of Tübingen, Elfriede-Aulhorn-Strasse 7, 72076 Tübingen, Germany; Corresponding authorSummary: The vertebrate inner retina is driven by photoreceptors whose outputs are already pre-processed; in zebrafish, outer retinal circuits split “color” from “grayscale” information across four cone-photoreceptor types. It remains unclear how the inner retina processes incoming spectral information while also combining cone signals to shape grayscale functions. We address this question by imaging the light-driven responses of amacrine cells (ACs) and bipolar cells (BCs) in larval zebrafish in the presence and pharmacological absence of inner retinal inhibition. We find that ACs enhance opponency in some bipolar cells while at the same time suppressing pre-existing opponency in others, so that, depending on the retinal region, the net change in the number of color-opponent units is essentially zero. To achieve this “dynamic balance,” ACs counteract intrinsic color opponency of BCs via the On channel. Consistent with these observations, Off-stratifying ACs are exclusively achromatic, while all color-opponent ACs stratify in the On sublamina.http://www.sciencedirect.com/science/article/pii/S2211124723000669CP: Neuroscience |
| spellingShingle | Xinwei Wang Paul A. Roberts Takeshi Yoshimatsu Leon Lagnado Tom Baden Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina Cell Reports CP: Neuroscience |
| title | Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina |
| title_full | Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina |
| title_fullStr | Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina |
| title_full_unstemmed | Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina |
| title_short | Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina |
| title_sort | amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723000669 |
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