Exposure study on susceptible people - SPES: An integrative biomonitoring approach
Background: The evaluation of environmental exposure risk requires a global analysis of pollution phenomena, including biological effects and potentially correlated clinical outcomes in susceptible populations. Although human biomonitoring plays a fundamental role in assessing the degree of contamin...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021005560 |
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| author | Biancamaria Pierri Carlo Buonerba Andrea Pierri Antonio Pizzolante Amedeo Ferro Anna Crispo Valentina Bollati Tiffany R. Sanchez Maria Grazia Andreassi Mauro Esposito Pellegrino Cerino |
| author_facet | Biancamaria Pierri Carlo Buonerba Andrea Pierri Antonio Pizzolante Amedeo Ferro Anna Crispo Valentina Bollati Tiffany R. Sanchez Maria Grazia Andreassi Mauro Esposito Pellegrino Cerino |
| author_sort | Biancamaria Pierri |
| collection | DOAJ |
| description | Background: The evaluation of environmental exposure risk requires a global analysis of pollution phenomena, including biological effects and potentially correlated clinical outcomes in susceptible populations. Although human biomonitoring plays a fundamental role in assessing the degree of contamination, it is not effective alone in identifying a direct link between exposure, biomolecular effects and outcomes on target organisms. While toxicogenomics and epidemiology are mainly focused on the investigation of molecular reactions and clinical outcomes, the monitoring of environmental matrices works independently to characterize the territorial distribution of toxic compounds, without proving any correlated health risk for residents. Objectives: We propose a new biomonitoring model based on a whole systemic analytical evaluation of environmental context. The paradigm of the method consists of identifying the sources of pollution, the migration pathways of those pollutants and their effects on target organisms. By means of this innovative, holistic epidemiological approach, we included healthy human subjects in a cohort to identify potential risks of exposure and predict possible correlated clinical outcomes. 4205 residents of the Campania region were enrolled in the “SPES” biomonitoring study, which especially focused on the areas dubbed “Land of Fires” in the recent decades. Discussion: The analysis of environmental exposure risk suffers the lack of data integration from various science fields, and this comes down to a limited point of view and a limited knowledge of phenomena.In implementing our model, we first constructed an analytical picture of the Real-world situation. We next conducted a comparative risk assessment, in order to identify possible correlations between pollution and health within a holistic view. Conclusion: This type of research activities aims to support the implementation of public health interventions and to become a reference model in the evaluation of the risk of exposure to environmental pollutants. |
| first_indexed | 2024-12-22T20:14:39Z |
| format | Article |
| id | doaj.art-f116dd3e94184f29809914a5e173a87a |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-22T20:14:39Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-f116dd3e94184f29809914a5e173a87a2022-12-21T18:14:00ZengElsevierEnvironment International0160-41202022-01-01158106931Exposure study on susceptible people - SPES: An integrative biomonitoring approachBiancamaria Pierri0Carlo Buonerba1Andrea Pierri2Antonio Pizzolante3Amedeo Ferro4Anna Crispo5Valentina Bollati6Tiffany R. Sanchez7Maria Grazia Andreassi8Mauro Esposito9Pellegrino Cerino10Centro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), Italy; Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, (SA), Italy; Corresponding author at: Centro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Portici, Italy.Centro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), ItalyCentro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), ItalyCentro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), ItalyCentro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), ItalyEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, 80131 Naples, ItalyEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, ItalyDepartment of Environmental Health Sciences, Columbia University, 10032 New York, NY, USAClinical Physiology Institute, National Research Council of Italy (IFC-CNR), Pisa, ItalyCentro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), ItalyCentro di Referenza Nazionale per l’analisi e studio di correlazione tra ambiente, animale e uomo, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, (NA), ItalyBackground: The evaluation of environmental exposure risk requires a global analysis of pollution phenomena, including biological effects and potentially correlated clinical outcomes in susceptible populations. Although human biomonitoring plays a fundamental role in assessing the degree of contamination, it is not effective alone in identifying a direct link between exposure, biomolecular effects and outcomes on target organisms. While toxicogenomics and epidemiology are mainly focused on the investigation of molecular reactions and clinical outcomes, the monitoring of environmental matrices works independently to characterize the territorial distribution of toxic compounds, without proving any correlated health risk for residents. Objectives: We propose a new biomonitoring model based on a whole systemic analytical evaluation of environmental context. The paradigm of the method consists of identifying the sources of pollution, the migration pathways of those pollutants and their effects on target organisms. By means of this innovative, holistic epidemiological approach, we included healthy human subjects in a cohort to identify potential risks of exposure and predict possible correlated clinical outcomes. 4205 residents of the Campania region were enrolled in the “SPES” biomonitoring study, which especially focused on the areas dubbed “Land of Fires” in the recent decades. Discussion: The analysis of environmental exposure risk suffers the lack of data integration from various science fields, and this comes down to a limited point of view and a limited knowledge of phenomena.In implementing our model, we first constructed an analytical picture of the Real-world situation. We next conducted a comparative risk assessment, in order to identify possible correlations between pollution and health within a holistic view. Conclusion: This type of research activities aims to support the implementation of public health interventions and to become a reference model in the evaluation of the risk of exposure to environmental pollutants.http://www.sciencedirect.com/science/article/pii/S0160412021005560Human BiomonitoringEnvironmentPublic HealthPollutionExposureCampania region |
| spellingShingle | Biancamaria Pierri Carlo Buonerba Andrea Pierri Antonio Pizzolante Amedeo Ferro Anna Crispo Valentina Bollati Tiffany R. Sanchez Maria Grazia Andreassi Mauro Esposito Pellegrino Cerino Exposure study on susceptible people - SPES: An integrative biomonitoring approach Environment International Human Biomonitoring Environment Public Health Pollution Exposure Campania region |
| title | Exposure study on susceptible people - SPES: An integrative biomonitoring approach |
| title_full | Exposure study on susceptible people - SPES: An integrative biomonitoring approach |
| title_fullStr | Exposure study on susceptible people - SPES: An integrative biomonitoring approach |
| title_full_unstemmed | Exposure study on susceptible people - SPES: An integrative biomonitoring approach |
| title_short | Exposure study on susceptible people - SPES: An integrative biomonitoring approach |
| title_sort | exposure study on susceptible people spes an integrative biomonitoring approach |
| topic | Human Biomonitoring Environment Public Health Pollution Exposure Campania region |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021005560 |
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