A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. T...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/20/4/1098 |
| _version_ | 1798004894883381248 |
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| author | Zheyuan Chen Christopher Wright Onder Dincel Ting-Yen Chi Jun Kameoka |
| author_facet | Zheyuan Chen Christopher Wright Onder Dincel Ting-Yen Chi Jun Kameoka |
| author_sort | Zheyuan Chen |
| collection | DOAJ |
| description | For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities. |
| first_indexed | 2024-04-11T12:30:42Z |
| format | Article |
| id | doaj.art-f11b90dab376471f988d9d04b769bf7e |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T12:30:42Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-f11b90dab376471f988d9d04b769bf7e2022-12-22T04:23:46ZengMDPI AGSensors1424-82202020-02-01204109810.3390/s20041098s20041098A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline ElectrodeZheyuan Chen0Christopher Wright1Onder Dincel2Ting-Yen Chi3Jun Kameoka4Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77840, USADepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77840, USADepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77840, USADepartment of Materials Science and Engineering, Texas A&M University, College Station, TX 77840, USADepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77840, USAFor the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities.https://www.mdpi.com/1424-8220/20/4/1098low costenzyme freepaper sensormolecular imprintingpolyanilineglucose sensing |
| spellingShingle | Zheyuan Chen Christopher Wright Onder Dincel Ting-Yen Chi Jun Kameoka A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode Sensors low cost enzyme free paper sensor molecular imprinting polyaniline glucose sensing |
| title | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
| title_full | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
| title_fullStr | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
| title_full_unstemmed | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
| title_short | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
| title_sort | low cost paper glucose sensor with molecularly imprinted polyaniline electrode |
| topic | low cost enzyme free paper sensor molecular imprinting polyaniline glucose sensing |
| url | https://www.mdpi.com/1424-8220/20/4/1098 |
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