Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity
The orbitofrontal cortex (OFC) is involved in cognitive functions, and is also closely related to autonomic functions. The OFC is densely connected with the hypothalamus, a heterogeneous structure controlling autonomic functions that can be divided into two major parts: the lateral and the medial. R...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00244/full |
| _version_ | 1811310205327114240 |
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| author | Satoshi eHirose Takahiro eOsada Akitoshi eOgawa Masaki eTanaka Hiroyuki eWada Yasunori eYoshizawa Yoshio eImai Toru eMachida Masaaki eAkahane Ichiro eShirouzu Seiki eKonishi |
| author_facet | Satoshi eHirose Takahiro eOsada Akitoshi eOgawa Masaki eTanaka Hiroyuki eWada Yasunori eYoshizawa Yoshio eImai Toru eMachida Masaaki eAkahane Ichiro eShirouzu Seiki eKonishi |
| author_sort | Satoshi eHirose |
| collection | DOAJ |
| description | The orbitofrontal cortex (OFC) is involved in cognitive functions, and is also closely related to autonomic functions. The OFC is densely connected with the hypothalamus, a heterogeneous structure controlling autonomic functions that can be divided into two major parts: the lateral and the medial. Resting-state functional connectivity has allowed us to parcellate the cerebral cortex into putative functional areas based on the changes in the spatial pattern of connectivity in the cerebral cortex when a seed point is moved from one voxel to another. In the present high spatial-resolution fMRI study, we investigate the connectivity-based organization of the OFC with reference to the hypothalamus. The OFC was parcellated using resting-state functional connectivity in an individual subject approach, and then the functional connectivity was examined between the parcellated areas in the OFC and the lateral/medial hypothalamus. We found a functional double dissociation in the OFC: the lateral OFC (the lateral orbital gyrus) was more likely connected with the lateral hypothalamus, whereas the medial OFC (the medial orbital and rectal gyri) was more likely connected with the medial hypothalamus. These results demonstrate the fundamental heterogeneity of the OFC, and suggest a potential neural basis of the OFC-hypothalamic functional interaction. |
| first_indexed | 2024-04-13T09:54:14Z |
| format | Article |
| id | doaj.art-f11c3a119fcd4921a6d4db4605b44c06 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T09:54:14Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-f11c3a119fcd4921a6d4db4605b44c062022-12-22T02:51:29ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-05-011010.3389/fnhum.2016.00244202718Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivitySatoshi eHirose0Takahiro eOsada1Akitoshi eOgawa2Masaki eTanaka3Hiroyuki eWada4Yasunori eYoshizawa5Yoshio eImai6Toru eMachida7Masaaki eAkahane8Ichiro eShirouzu9Seiki eKonishi10Juntendo UniveristyJuntendo UniveristyJuntendo UniveristyJuntendo UniveristyNTT Medical Center TokyoNTT Medical Center TokyoNTT Medical Center TokyoNTT Medical Center TokyoNTT Medical Center TokyoNTT Medical Center TokyoJuntendo UniveristyThe orbitofrontal cortex (OFC) is involved in cognitive functions, and is also closely related to autonomic functions. The OFC is densely connected with the hypothalamus, a heterogeneous structure controlling autonomic functions that can be divided into two major parts: the lateral and the medial. Resting-state functional connectivity has allowed us to parcellate the cerebral cortex into putative functional areas based on the changes in the spatial pattern of connectivity in the cerebral cortex when a seed point is moved from one voxel to another. In the present high spatial-resolution fMRI study, we investigate the connectivity-based organization of the OFC with reference to the hypothalamus. The OFC was parcellated using resting-state functional connectivity in an individual subject approach, and then the functional connectivity was examined between the parcellated areas in the OFC and the lateral/medial hypothalamus. We found a functional double dissociation in the OFC: the lateral OFC (the lateral orbital gyrus) was more likely connected with the lateral hypothalamus, whereas the medial OFC (the medial orbital and rectal gyri) was more likely connected with the medial hypothalamus. These results demonstrate the fundamental heterogeneity of the OFC, and suggest a potential neural basis of the OFC-hypothalamic functional interaction.http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00244/fullBrain MappingFrontal LobeNeuroanatomyfunctional MRIorbitofrontal cortex |
| spellingShingle | Satoshi eHirose Takahiro eOsada Akitoshi eOgawa Masaki eTanaka Hiroyuki eWada Yasunori eYoshizawa Yoshio eImai Toru eMachida Masaaki eAkahane Ichiro eShirouzu Seiki eKonishi Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity Frontiers in Human Neuroscience Brain Mapping Frontal Lobe Neuroanatomy functional MRI orbitofrontal cortex |
| title | Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity |
| title_full | Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity |
| title_fullStr | Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity |
| title_full_unstemmed | Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity |
| title_short | Lateral-medial dissociation in orbitofrontal cortex-hypothalamus connectivity |
| title_sort | lateral medial dissociation in orbitofrontal cortex hypothalamus connectivity |
| topic | Brain Mapping Frontal Lobe Neuroanatomy functional MRI orbitofrontal cortex |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00244/full |
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