Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients
Abstract Background Burkholderia cepacia (BC) has been detected more and more in infected patients in recent years. However, as a high-risk population, the clinical characteristics and prognosis of BC infection in hematopoietic stem cell transplantation (HSCT) patients have not been reported. The pu...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-022-07754-z |
| _version_ | 1811226578858803200 |
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| author | Yan Jia Ya Liu Yi Liu Kaitai Yang Yanfeng Liu |
| author_facet | Yan Jia Ya Liu Yi Liu Kaitai Yang Yanfeng Liu |
| author_sort | Yan Jia |
| collection | DOAJ |
| description | Abstract Background Burkholderia cepacia (BC) has been detected more and more in infected patients in recent years. However, as a high-risk population, the clinical characteristics and prognosis of BC infection in hematopoietic stem cell transplantation (HSCT) patients have not been reported. The purpose of this study is to obtain data that will help fill in the gaps in this field, provide evidence for reducing the mortality rate of BC infection in HSCT patients, and guide the use of antibiotics in the future. Methods Electronic medical records of patients with BC infection who underwent HSCT in Xiangya Hospital of Central South University from September 1, 2015 to August 31, 2021 were collected. At the same time, 1:1 case–control matching was conducted according to gender, age and disease type. Comparisons between patients with/without BC infection and respiratory failure were made respectively, and the sensitivity of BC to five clinically commonly used antibiotics was also evaluated. Univariate and multivariate analyses were performed to identify independent risk factors for death. Results The most common site of BC infection in HSCT patients was the lung (75%). Although BC infection rate (3.74%) and antibiotic resistance were not significant, it was closely associated with a higher risk of death (P = 0.022), which even further increased to 90.9% when combined with respiratory failure (P = 0.008). Procalcitonin > 10 µg/L (HR = 40.88, 95% CI 6.51–256.63, P = 0.000) and septic shock (HR = 4.08, 95% CI 1.02–16.33, P = 0.047) were two independent risk factors for death. Conclusion HSCT patients with BC infection are in critical condition, and the management of respiratory infection should be especially strengthened to improve the prognosis of these patients. |
| first_indexed | 2024-04-12T09:27:29Z |
| format | Article |
| id | doaj.art-f11d17d901a742a7b1ca673620a5e5ea |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T09:27:29Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-f11d17d901a742a7b1ca673620a5e5ea2022-12-22T03:38:28ZengBMCBMC Infectious Diseases1471-23342022-10-012211910.1186/s12879-022-07754-zClinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patientsYan Jia0Ya Liu1Yi Liu2Kaitai Yang3Yanfeng Liu4Department of Hematology, Xiangya Hospital, Central South UniversityDepartment of Gastroenterologyy, Xiangya Hospital, Central South UniversityDepartment of Hematology, Xiangya Hospital, Central South UniversityDepartment of Hematology, Xiangya Hospital, Central South UniversityDepartment of Hematology, Xiangya Hospital, Central South UniversityAbstract Background Burkholderia cepacia (BC) has been detected more and more in infected patients in recent years. However, as a high-risk population, the clinical characteristics and prognosis of BC infection in hematopoietic stem cell transplantation (HSCT) patients have not been reported. The purpose of this study is to obtain data that will help fill in the gaps in this field, provide evidence for reducing the mortality rate of BC infection in HSCT patients, and guide the use of antibiotics in the future. Methods Electronic medical records of patients with BC infection who underwent HSCT in Xiangya Hospital of Central South University from September 1, 2015 to August 31, 2021 were collected. At the same time, 1:1 case–control matching was conducted according to gender, age and disease type. Comparisons between patients with/without BC infection and respiratory failure were made respectively, and the sensitivity of BC to five clinically commonly used antibiotics was also evaluated. Univariate and multivariate analyses were performed to identify independent risk factors for death. Results The most common site of BC infection in HSCT patients was the lung (75%). Although BC infection rate (3.74%) and antibiotic resistance were not significant, it was closely associated with a higher risk of death (P = 0.022), which even further increased to 90.9% when combined with respiratory failure (P = 0.008). Procalcitonin > 10 µg/L (HR = 40.88, 95% CI 6.51–256.63, P = 0.000) and septic shock (HR = 4.08, 95% CI 1.02–16.33, P = 0.047) were two independent risk factors for death. Conclusion HSCT patients with BC infection are in critical condition, and the management of respiratory infection should be especially strengthened to improve the prognosis of these patients.https://doi.org/10.1186/s12879-022-07754-zBurkholderia cepaciaHematopoietic stem cell transplantationInfectionRespiratory failureDrug resistance |
| spellingShingle | Yan Jia Ya Liu Yi Liu Kaitai Yang Yanfeng Liu Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients BMC Infectious Diseases Burkholderia cepacia Hematopoietic stem cell transplantation Infection Respiratory failure Drug resistance |
| title | Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients |
| title_full | Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients |
| title_fullStr | Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients |
| title_full_unstemmed | Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients |
| title_short | Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients |
| title_sort | clinical characteristics drug resistance and death risk factors of burkholderia cepacia infection in hematopoietic stem cell transplant patients |
| topic | Burkholderia cepacia Hematopoietic stem cell transplantation Infection Respiratory failure Drug resistance |
| url | https://doi.org/10.1186/s12879-022-07754-z |
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