Synthesis and characterization of benzylidene- [1,3,4]thaidiazol -2-yl-amine
This study was designed to synthesize chemically 2-aminothiadiazole derivatives and conversion to Schiff’s base. The principle synthesis of these compounds was to involve three steps: First : by thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of potassium hydroxide di...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2006-06-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/405 |
| Summary: | This study was designed to synthesize chemically 2-aminothiadiazole derivatives and conversion to Schiff’s base. The principle synthesis of these compounds was to involve three steps:
First : by thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of potassium hydroxide dissolved in anhydrous ethanol to yield 2-amino-5- mercapto-1,3,4-thiadiazole.
Second : by thermal cyclization of thiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2-amino-5-R-1,3,4-thiadiazole.
Third : Schiff’s base formation by reflux of aromatic aldehyde with 2-amino-5-R-1,3,4-thiadiazole in the presence of ethanol.
The chemical structures of all prepared compounds were confirmed by spectral data (UV-visible and IR spectroscopy) tables (1, 2, and 3).
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| ISSN: | 1815-0993 2959-183X |